ID   DAZL_CHICK              Reviewed;         289 AA.
AC   Q804A9;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Deleted in azoospermia-like;
DE            Short=DAZ-like protein;
GN   Name=DAZL;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RA   Tsukada A., Kuroiwa A., Matsuda Y., Shimada K., Petitte J.N.;
RT   "Isolation and characterization of a cDNA clone encoding the germ cell-
RT   specific RNA binding protein dazl (deleted in azoospermia-like) from the
RT   chicken ovary.";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein, which probably plays a central role in
CC       gametogenesis in both males and females. Acts by binding to the 3'-UTR
CC       of mRNA, specifically recognizing GUU triplets, and promoting the
CC       translation of key transcripts (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRM DAZ family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01238}.
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DR   EMBL; AY211387; AAO26019.1; -; mRNA.
DR   RefSeq; NP_989549.1; NM_204218.1.
DR   AlphaFoldDB; Q804A9; -.
DR   SMR; Q804A9; -.
DR   STRING; 9031.ENSGALP00000043122; -.
DR   PaxDb; Q804A9; -.
DR   GeneID; 374054; -.
DR   KEGG; gga:374054; -.
DR   CTD; 1618; -.
DR   VEuPathDB; HostDB:geneid_374054; -.
DR   eggNOG; KOG0118; Eukaryota.
DR   InParanoid; Q804A9; -.
DR   OrthoDB; 1610446at2759; -.
DR   PhylomeDB; Q804A9; -.
DR   PRO; PR:Q804A9; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0005844; C:polysome; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR   GO; GO:0008494; F:translation activator activity; IBA:GO_Central.
DR   GO; GO:0070935; P:3'-UTR-mediated mRNA stabilization; IBA:GO_Central.
DR   GO; GO:0007147; P:female meiosis II; IEA:Ensembl.
DR   GO; GO:0001556; P:oocyte maturation; IEA:Ensembl.
DR   GO; GO:0045836; P:positive regulation of meiotic nuclear division; IEA:Ensembl.
DR   GO; GO:0045948; P:positive regulation of translational initiation; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   CDD; cd12672; RRM_DAZL; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR037366; BOULE/DAZ.
DR   InterPro; IPR043628; DAZ_dom.
DR   InterPro; IPR037551; DAZ_RRM_vert.
DR   InterPro; IPR034779; DAZL.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR11176; PTHR11176; 1.
DR   PANTHER; PTHR11176:SF4; PTHR11176:SF4; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS51890; DAZ; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; Oogenesis;
KW   Reference proteome; RNA-binding; Spermatogenesis; Translation regulation.
FT   CHAIN           1..289
FT                   /note="Deleted in azoospermia-like"
FT                   /id="PRO_0000081563"
FT   DOMAIN          36..117
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          162..187
FT                   /note="DAZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01238"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   289 AA;  32717 MW;  39EC2D364111A076 CRC64;
     MSANAEAQCG SISEDNTHSS TTCQGYVLPE GKIMPNTVFV GGIDIRMNEA EIRSYFEQYG
     TVKEVKIITD RTGVSKGYGF VSFLDNVDVQ KIVESQISVH GKRLKLGPAI RKQQNLCSYM
     QPRPLAFNPP APQFHSVWTN QNTETYVQPQ AVVSPLTQYV QTYAYSSPAV LIQQQVPVGY
     QPAYNYQAPP QWVPGEQRNY VMPPVYTSVN YHYSEDPEFI QTECAVPEPT QMSGNSPQKK
     SVDRSIQTVV SCLFNPENRL RNTFVSQEDY FRERRAHHFR KGRAVLKSV