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DAZL_HUMAN
ID   DAZL_HUMAN              Reviewed;         295 AA.
AC   Q92904; O15396; Q5HYB4; Q92909;
DT   17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 189.
DE   RecName: Full=Deleted in azoospermia-like;
DE   AltName: Full=DAZ homolog;
DE   AltName: Full=DAZ-like autosomal;
DE   AltName: Full=Deleted in azoospermia-like 1;
DE   AltName: Full=SPGY-like-autosomal;
GN   Name=DAZL; Synonyms=DAZH, DAZL1, DAZLA, SPGYLA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=8896558; DOI=10.1038/ng1196-292;
RA   Saxena R., Brown L.G., Hawkins T., Alagappan R.K., Skaletsky H.,
RA   Reeve M.P., Reijo R.A., Rozen S., Dinulos M.B., Disteche C.M., Page D.C.;
RT   "The DAZ gene cluster on the human Y chromosome arose from an autosomal
RT   gene that was transposed, repeatedly amplified and pruned.";
RL   Nat. Genet. 14:292-299(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=8968755; DOI=10.1093/hmg/5.12.2005;
RA   Shan Z., Hirschmann P., Seebacher T., Edelmann A., Jauch A., Morell J.,
RA   Urbitsch P., Vogt P.H.;
RT   "A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene
RT   boule is autosomal and expressed only in the human male gonad.";
RL   Hum. Mol. Genet. 5:2005-2011(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=8968756; DOI=10.1093/hmg/5.12.2013;
RA   Yen P.H., Chai N.-N., Salido E.C.;
RT   "The human autosomal gene DAZLA: testis specificity and a candidate for
RT   male infertility.";
RL   Hum. Mol. Genet. 5:2013-2017(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RX   PubMed=9294855; DOI=10.1093/molehr/3.8.705;
RA   Chai N.-N., Phillips A., Fernandez A., Yen P.H.;
RT   "A putative human male infertility gene DAZLA: genomic structure and
RT   methylation status.";
RL   Mol. Hum. Reprod. 3:705-708(1997).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [10]
RP   DOMAIN, AND INTERACTION WITH DAZAP1 AND DAZAP2.
RC   TISSUE=Testis;
RX   PubMed=10857750; DOI=10.1006/geno.2000.6169;
RA   Tsui S., Dai T., Roettger S., Schempp W., Salido E.C., Yen P.H.;
RT   "Identification of two novel proteins that interact with germ-cell-specific
RT   RNA-binding proteins DAZ and DAZL1.";
RL   Genomics 65:266-273(2000).
RN   [11]
RP   INTERACTION WITH BOLL.
RX   PubMed=11390979; DOI=10.1073/pnas.131090498;
RA   Xu E.Y., Moore F.L., Reijo Pera R.A.;
RT   "A gene family required for human germ cell development evolved from an
RT   ancient meiotic gene conserved in metazoans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7414-7419(2001).
RN   [12]
RP   INTERACTION WITH PUM2.
RX   PubMed=12511597; DOI=10.1073/pnas.0234478100;
RA   Moore F.L., Jaruzelska J., Fox M.S., Urano J., Firpo M.T., Turek P.J.,
RA   Dorfman D.M., Reijo Pera R.A.;
RT   "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and
RT   interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:538-543(2003).
RN   [13]
RP   VARIANTS ALA-12 AND ALA-54.
RX   PubMed=12414900; DOI=10.1210/jc.2002-020016;
RA   Teng Y.-N., Lin Y.-M., Lin Y.-H., Tsao S.-Y., Hsu C.-C., Lin S.-J.,
RA   Tsai W.-C., Kuo P.-L.;
RT   "Association of a single-nucleotide polymorphism of the deleted-in-
RT   azoospermia-like gene with susceptibility to spermatogenic failure.";
RL   J. Clin. Endocrinol. Metab. 87:5258-5264(2002).
RN   [14]
RP   VARIANT GLY-115.
RX   PubMed=22021443; DOI=10.1073/pnas.1105211108;
RA   Jenkins H.T., Malkova B., Edwards T.A.;
RT   "Kinked beta-strands mediate high-affinity recognition of mRNA targets by
RT   the germ-cell regulator DAZL.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:18266-18271(2011).
CC   -!- FUNCTION: RNA-binding protein, which is essential for gametogenesis in
CC       both males and females. Plays a central role during spermatogenesis.
CC       Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU
CC       triplets, and thereby regulating the translation of key transcripts (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer and heterodimer. Multiple DAZL RRMs can bind to a
CC       single RNA containing multiple GUU triplets (By similarity). Forms a
CC       heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts
CC       with PUM2. {ECO:0000250, ECO:0000269|PubMed:10857750,
CC       ECO:0000269|PubMed:11390979, ECO:0000269|PubMed:12511597}.
CC   -!- INTERACTION:
CC       Q92904; Q9NQZ3: DAZ1; NbExp=2; IntAct=EBI-998153, EBI-997955;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Predominantly cytoplasmic. Nuclear in spermatogonia until near the
CC       end of the meiotic prophase and cytoplasmic localization from then
CC       onward. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q92904-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q92904-2; Sequence=VSP_043208;
CC   -!- TISSUE SPECIFICITY: Testis specific. {ECO:0000269|PubMed:8896558,
CC       ECO:0000269|PubMed:8968755, ECO:0000269|PubMed:8968756}.
CC   -!- DOMAIN: The DAZ domain mediates the interaction with DAZAP1 and DAZAP2.
CC       {ECO:0000269|PubMed:10857750}.
CC   -!- SIMILARITY: Belongs to the RRM DAZ family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01238}.
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DR   EMBL; U65918; AAC50813.1; -; mRNA.
DR   EMBL; U66726; AAB39935.1; -; mRNA.
DR   EMBL; U66078; AAB63596.1; -; mRNA.
DR   EMBL; U77476; AAB84361.1; -; Genomic_DNA.
DR   EMBL; U77467; AAB84361.1; JOINED; Genomic_DNA.
DR   EMBL; U77468; AAB84361.1; JOINED; Genomic_DNA.
DR   EMBL; U77469; AAB84361.1; JOINED; Genomic_DNA.
DR   EMBL; U77470; AAB84361.1; JOINED; Genomic_DNA.
DR   EMBL; U77471; AAB84361.1; JOINED; Genomic_DNA.
DR   EMBL; U77472; AAB84361.1; JOINED; Genomic_DNA.
DR   EMBL; U77473; AAB84361.1; JOINED; Genomic_DNA.
DR   EMBL; U77474; AAB84361.1; JOINED; Genomic_DNA.
DR   EMBL; U77475; AAB84361.1; JOINED; Genomic_DNA.
DR   EMBL; AK303026; BAG64152.1; -; mRNA.
DR   EMBL; BX648638; CAI45996.1; -; mRNA.
DR   EMBL; AC010139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471055; EAW64279.1; -; Genomic_DNA.
DR   EMBL; BC027595; AAH27595.1; -; mRNA.
DR   CCDS; CCDS43059.1; -. [Q92904-1]
DR   CCDS; CCDS54556.1; -. [Q92904-2]
DR   RefSeq; NP_001177740.1; NM_001190811.1. [Q92904-2]
DR   RefSeq; NP_001342.2; NM_001351.3. [Q92904-1]
DR   AlphaFoldDB; Q92904; -.
DR   SMR; Q92904; -.
DR   BioGRID; 107987; 145.
DR   IntAct; Q92904; 5.
DR   STRING; 9606.ENSP00000250863; -.
DR   iPTMnet; Q92904; -.
DR   PhosphoSitePlus; Q92904; -.
DR   BioMuta; DAZL; -.
DR   DMDM; 27805453; -.
DR   EPD; Q92904; -.
DR   MassIVE; Q92904; -.
DR   PaxDb; Q92904; -.
DR   PeptideAtlas; Q92904; -.
DR   PRIDE; Q92904; -.
DR   ProteomicsDB; 75589; -. [Q92904-1]
DR   ProteomicsDB; 75590; -. [Q92904-2]
DR   Antibodypedia; 6122; 329 antibodies from 38 providers.
DR   DNASU; 1618; -.
DR   Ensembl; ENST00000250863.12; ENSP00000250863.8; ENSG00000092345.14. [Q92904-2]
DR   Ensembl; ENST00000399444.7; ENSP00000382373.3; ENSG00000092345.14. [Q92904-1]
DR   GeneID; 1618; -.
DR   KEGG; hsa:1618; -.
DR   MANE-Select; ENST00000399444.7; ENSP00000382373.3; NM_001351.4; NP_001342.2.
DR   UCSC; uc003cba.4; human. [Q92904-1]
DR   CTD; 1618; -.
DR   DisGeNET; 1618; -.
DR   GeneCards; DAZL; -.
DR   HGNC; HGNC:2685; DAZL.
DR   HPA; ENSG00000092345; Tissue enriched (testis).
DR   MIM; 601486; gene.
DR   neXtProt; NX_Q92904; -.
DR   OpenTargets; ENSG00000092345; -.
DR   PharmGKB; PA27155; -.
DR   VEuPathDB; HostDB:ENSG00000092345; -.
DR   eggNOG; KOG0118; Eukaryota.
DR   GeneTree; ENSGT00530000063480; -.
DR   HOGENOM; CLU_084802_0_0_1; -.
DR   InParanoid; Q92904; -.
DR   OMA; QSECSVH; -.
DR   OrthoDB; 1610446at2759; -.
DR   PhylomeDB; Q92904; -.
DR   TreeFam; TF324396; -.
DR   PathwayCommons; Q92904; -.
DR   SignaLink; Q92904; -.
DR   BioGRID-ORCS; 1618; 33 hits in 1065 CRISPR screens.
DR   ChiTaRS; DAZL; human.
DR   GeneWiki; DAZL; -.
DR   GenomeRNAi; 1618; -.
DR   Pharos; Q92904; Tbio.
DR   PRO; PR:Q92904; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q92904; protein.
DR   Bgee; ENSG00000092345; Expressed in oocyte and 54 other tissues.
DR   ExpressionAtlas; Q92904; baseline and differential.
DR   Genevisible; Q92904; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; TAS:ProtInc.
DR   GO; GO:0008494; F:translation activator activity; IDA:UniProtKB.
DR   GO; GO:0070935; P:3'-UTR-mediated mRNA stabilization; IBA:GO_Central.
DR   GO; GO:0007281; P:germ cell development; TAS:ProtInc.
DR   GO; GO:0045948; P:positive regulation of translational initiation; IDA:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   CDD; cd12672; RRM_DAZL; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR037366; BOULE/DAZ.
DR   InterPro; IPR043628; DAZ_dom.
DR   InterPro; IPR037551; DAZ_RRM_vert.
DR   InterPro; IPR034779; DAZL.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR11176; PTHR11176; 1.
DR   PANTHER; PTHR11176:SF4; PTHR11176:SF4; 1.
DR   Pfam; PF18872; Daz; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS51890; DAZ; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cytoplasm; Developmental protein; Differentiation;
KW   Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Spermatogenesis;
KW   Translation regulation.
FT   CHAIN           1..295
FT                   /note="Deleted in azoospermia-like"
FT                   /id="PRO_0000081559"
FT   DOMAIN          40..115
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          167..190
FT                   /note="DAZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01238"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          80..132
FT                   /note="Homodimerization"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         276
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q64368"
FT   VAR_SEQ         1
FT                   /note="M -> MAAPSCGGDRKARLTPSLPHE (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:17974005"
FT                   /id="VSP_043208"
FT   VARIANT         12
FT                   /note="T -> A (in dbSNP:rs11710967)"
FT                   /evidence="ECO:0000269|PubMed:12414900"
FT                   /id="VAR_017780"
FT   VARIANT         54
FT                   /note="T -> A (may be associated with susceptibility to
FT                   spermatogenic failure in Asian individuals; this
FT                   substitution may lead to affect the DAZL transcript
FT                   stability and prevent its translation; dbSNP:rs121918346)"
FT                   /evidence="ECO:0000269|PubMed:12414900"
FT                   /id="VAR_017781"
FT   VARIANT         115
FT                   /note="R -> G (severely impaired RNA-binding)"
FT                   /evidence="ECO:0000269|PubMed:22021443"
FT                   /id="VAR_069231"
FT   CONFLICT        3
FT                   /note="T -> I (in Ref. 3; AAB63596)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        253
FT                   /note="Q -> R (in Ref. 4; AAB84361)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   295 AA;  33178 MW;  21B360739B35B95F CRC64;
     MSTANPETPN STISREASTQ SSSAATSQGY ILPEGKIMPN TVFVGGIDVR MDETEIRSFF
     ARYGSVKEVK IITDRTGVSK GYGFVSFFND VDVQKIVESQ INFHGKKLKL GPAIRKQNLC
     AYHVQPRPLV FNHPPPPQFQ NVWTNPNTET YMQPTTTMNP ITQYVQAYPT YPNSPVQVIT
     GYQLPVYNYQ MPPQWPVGEQ RSYVVPPAYS AVNYHCNEVD PGAEVVPNEC SVHEATPPSG
     NGPQKKSVDR SIQTVVSCLF NPENRLRNSV VTQDDYFKDK RVHHFRRSRA MLKSV
 
 
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