DAZL_MACFA
ID DAZL_MACFA Reviewed; 295 AA.
AC Q95192; Q9BGN7;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 17-JAN-2003, sequence version 3.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Deleted in azoospermia-like;
DE AltName: Full=DAZ-like autosomal;
DE AltName: Full=Deleted in azoospermia-like 1;
GN Name=DAZL; Synonyms=DAZL1, DAZLA;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=9239736; DOI=10.1093/molehr/3.6.479;
RA Carani C., Gromoll J., Brinkworth M.H., Simoni M., Weinbauer G.F.W.,
RA Nieschlag E.;
RT "cynDAZLA: a cynomolgus monkey homologue of the human autosomal DAZ gene.";
RL Mol. Hum. Reprod. 3:479-483(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=11079458; DOI=10.1007/bf03343785;
RA Grossmann B., Weinbauer G., Hirschmann P., Vogt P.H.;
RT "Conservation of the deleted-in-azoospermia-like-1 (DAZL1) gene structure
RT in old world monkeys points to a homologous function of DAZL1 in this
RT primate class.";
RL J. Endocrinol. Invest. 23:616-622(2000).
CC -!- FUNCTION: RNA-binding protein, which is essential for gametogenesis in
CC both males and females. Plays a central role during spermatogenesis.
CC Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU
CC triplets, and thereby regulating the translation of key transcripts (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer and heterodimer. Forms a heterodimer with DAZ.
CC Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2 Multiple
CC DAZL RRMs can bind to a single RNA containing multiple GUU triplets (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=Predominantly cytoplasmic. Nuclear in spermatogonia until near the
CC end of the meiotic prophase and cytoplasmic localization from then
CC onward. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Testis specific. {ECO:0000269|PubMed:9239736}.
CC -!- DOMAIN: The DAZ domain mediates the interaction with DAZAP1 and DAZAP2.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RRM DAZ family. {ECO:0000255|PROSITE-
CC ProRule:PRU01238}.
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DR EMBL; X99971; CAA68233.1; -; mRNA.
DR EMBL; AF144132; AAG50426.1; -; mRNA.
DR RefSeq; NP_001270735.1; NM_001283806.1.
DR AlphaFoldDB; Q95192; -.
DR SMR; Q95192; -.
DR STRING; 9541.XP_005545745.1; -.
DR PRIDE; Q95192; -.
DR Ensembl; ENSMFAT00000024154; ENSMFAP00000005477; ENSMFAG00000002406.
DR GeneID; 102121570; -.
DR CTD; 1618; -.
DR VEuPathDB; HostDB:ENSMFAG00000002406; -.
DR eggNOG; KOG0118; Eukaryota.
DR GeneTree; ENSGT00530000063480; -.
DR OMA; QSECSVH; -.
DR OrthoDB; 1610446at2759; -.
DR Proteomes; UP000233100; Chromosome 2.
DR Bgee; ENSMFAG00000002406; Expressed in multicellular organism.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:InterPro.
DR GO; GO:0008494; F:translation activator activity; IEA:Ensembl.
DR GO; GO:0007281; P:germ cell development; IEA:InterPro.
DR GO; GO:0045948; P:positive regulation of translational initiation; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd12672; RRM_DAZL; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR037366; BOULE/DAZ.
DR InterPro; IPR043628; DAZ_dom.
DR InterPro; IPR037551; DAZ_RRM_vert.
DR InterPro; IPR034779; DAZL.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR11176; PTHR11176; 1.
DR PANTHER; PTHR11176:SF4; PTHR11176:SF4; 1.
DR Pfam; PF18872; Daz; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS51890; DAZ; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; Differentiation; Nucleus; Phosphoprotein;
KW Reference proteome; RNA-binding; Spermatogenesis; Translation regulation.
FT CHAIN 1..295
FT /note="Deleted in azoospermia-like"
FT /id="PRO_0000081560"
FT DOMAIN 40..115
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 167..190
FT /note="DAZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01238"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..132
FT /note="Homodimerization"
FT /evidence="ECO:0000250"
FT MOD_RES 276
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q64368"
FT CONFLICT 288
FT /note="S -> I (in Ref. 1; CAA68233)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 295 AA; 33114 MW; D95EDF9097812764 CRC64;
MSAANPETPN STISREASTQ SSSAAASQGY VLPEGKIMPN TVFVGGIDVR MDETEIRSFF
ARYGSVKEVK IITDRTGVSK GYGFVSFFND VDVQKIVESQ INFHGKKLKL GPAIRKQNLC
AYHVQPRPLV FNHPPPPQFQ NVWTNPNTET YMQPPTTMNP ITQYVQAYPT YPNSPVQVIT
GYQLPVYNYQ MPPQWPVGEQ RSYVVPPAYS AVNYHCNEVD PGAEVVPNEC SVHEATPPSG
NGPQKKSVDR SIQTVVSCLF NPENRLRNTV VTQDDYFKDK RVHHFRRSRA MLKSV
