DAZL_XENTR
ID DAZL_XENTR Reviewed; 286 AA.
AC Q76CY5;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Deleted in azoospermia-like;
DE Short=DAZ-like protein;
DE AltName: Full=Xtdazl;
GN Name=dazl {ECO:0000312|EMBL:BAC99992.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAC99992.1}
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Embryo {ECO:0000269|PubMed:14745962};
RX PubMed=14745962; DOI=10.1002/dvdy.10448;
RA Sekizaki H., Takahashi S., Tanegashima K., Onuma Y., Haramoto Y.,
RA Asashima M.;
RT "Tracing of Xenopus tropicalis germ plasm and presumptive primordial germ
RT cells with the Xenopus tropicalis DAZ-like gene.";
RL Dev. Dyn. 229:367-372(2004).
RN [2] {ECO:0000312|EMBL:AAH67947.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH67947.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA-binding protein that is required for primordial germ cell
CC (PGC) differentiation and indirectly necessary for the migration of
CC PGCs through the endoderm. May promote meiotic cell division during
CC spermatogenesis. Shows a preference for G- and U-rich RNAs and probably
CC binds the 3'-UTR of target mRNAs. Stimulates the initiation of
CC translation of mRNAs through the recruitment of poly(A)-binding
CC proteins (PABPs) (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the C-terminus of pabp1 and with epabp. Prior
CC to oocyte maturation, found in a complex with epabp and pum2 proteins
CC and spdy1 mRNA; pum2 dissociates from the complex during maturation (By
CC similarity). {ECO:0000250|UniProtKB:O57437}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14745962}.
CC -!- TISSUE SPECIFICITY: Germ-line specific; expressed in adult testis and
CC ovary. Localized specifically to the oocyte and embryonic germ plasm
CC and to migrating primordial germ cells (PGCs).
CC {ECO:0000269|PubMed:14745962}.
CC -!- DEVELOPMENTAL STAGE: Expressed constantly during oogenesis from the
CC previtellogenic (stage I) oocyte to the mature (stage VI) oocyte, and
CC after fertilization until the early tadpole stage.
CC {ECO:0000269|PubMed:14745962}.
CC -!- SIMILARITY: Belongs to the RRM DAZ family. {ECO:0000255|PROSITE-
CC ProRule:PRU01238}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB109328; BAC99992.1; -; mRNA.
DR EMBL; BC067947; AAH67947.1; -; mRNA.
DR RefSeq; NP_989079.1; NM_203748.1.
DR AlphaFoldDB; Q76CY5; -.
DR SMR; Q76CY5; -.
DR STRING; 8364.ENSXETP00000051550; -.
DR PaxDb; Q76CY5; -.
DR DNASU; 394676; -.
DR GeneID; 394676; -.
DR KEGG; xtr:394676; -.
DR CTD; 1618; -.
DR Xenbase; XB-GENE-1006218; dazl.
DR eggNOG; KOG0118; Eukaryota.
DR HOGENOM; CLU_084802_0_0_1; -.
DR InParanoid; Q76CY5; -.
DR OMA; QSECSVH; -.
DR OrthoDB; 1610446at2759; -.
DR PhylomeDB; Q76CY5; -.
DR TreeFam; TF324396; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000025199; Expressed in testis and 14 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0032019; C:mitochondrial cloud; ISS:UniProtKB.
DR GO; GO:0045495; C:pole plasm; IDA:UniProtKB.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR GO; GO:0008494; F:translation activator activity; ISS:UniProtKB.
DR GO; GO:0070935; P:3'-UTR-mediated mRNA stabilization; IBA:GO_Central.
DR GO; GO:0007281; P:germ cell development; ISS:UniProtKB.
DR GO; GO:0008354; P:germ cell migration; ISS:UniProtKB.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0045948; P:positive regulation of translational initiation; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd12672; RRM_DAZL; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR037366; BOULE/DAZ.
DR InterPro; IPR043628; DAZ_dom.
DR InterPro; IPR037551; DAZ_RRM_vert.
DR InterPro; IPR034779; DAZL.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR11176; PTHR11176; 1.
DR PANTHER; PTHR11176:SF4; PTHR11176:SF4; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS51890; DAZ; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; Differentiation; Oogenesis;
KW Reference proteome; RNA-binding; Spermatogenesis; Translation regulation.
FT CHAIN 1..286
FT /note="Deleted in azoospermia-like"
FT /id="PRO_0000248851"
FT DOMAIN 30..105
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 155..180
FT /note="DAZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01238"
SQ SEQUENCE 286 AA; 31927 MW; 257DB58428FB39B8 CRC64;
MSATEASAGE EAASATSQAF VLPEGKVIPN TVFVGGIDIT MDEMAIGNLF EKYGKVKDLK
IITDRTGVSK GYGFVSFYDE VDVQKIVKSQ INFHGKKLKL GPAIRKMQRI CTYVQTSPVV
ISPPTQFHPT WNSQNADSYI QHSPIISPVT QYVQACPYPS SPPMAIQQIP VGCQQPSYFQ
VSPQWPTDQR NYMFPSPAFT FNYNCCEIDP NGGEPMPREY HIDQAVSASG ANLQKRYVDM
STQTIISCLF DPAKKVRLFA SQEDYIQDDS VHQFRRSKSV IKRVSN
