DAZP2_HUMAN
ID DAZP2_HUMAN Reviewed; 168 AA.
AC Q15038; A8K254; B4DDT5; B4E1G3; C9JA96; C9JP84; E9PB45; F8VU62;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=DAZ-associated protein 2;
DE AltName: Full=Deleted in azoospermia-associated protein 2;
GN Name=DAZAP2; Synonyms=KIAA0058;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND SUBCELLULAR LOCATION.
RC TISSUE=Bone marrow;
RX PubMed=17935665;
RA Shi Y.-W., Shen R., Ren W., Tang L.J., Tan D.-R., Hu W.-X.;
RT "Molecular features and expression of DAZAP2 in human multiple myeloma.";
RL Chin. Med. J. 120:1659-1665(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RC TISSUE=Erythroblast;
RA Gubin A.N., Lee Y.T., Bouffard G.G., Miller J.L.;
RT "Gene expression in human erythroid precursor cells.";
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Bone marrow;
RX PubMed=7584044; DOI=10.1093/dnares/1.5.223;
RA Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N.,
RA Kawarabayasi Y., Ishikawa K., Tabata S.;
RT "Prediction of the coding sequences of unidentified human genes. II. The
RT coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of
RT cDNA clones from human cell line KG-1.";
RL DNA Res. 1:223-229(1994).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Fetal brain;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5).
RC TISSUE=Lung, Mammary gland, and Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=B-cell, and Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP TISSUE SPECIFICITY, AND INTERACTION WITH DAZ1 AND DAZL.
RC TISSUE=Testis;
RX PubMed=10857750; DOI=10.1006/geno.2000.6169;
RA Tsui S., Dai T., Roettger S., Schempp W., Salido E.C., Yen P.H.;
RT "Identification of two novel proteins that interact with germ-cell-specific
RT RNA-binding proteins DAZ and DAZL1.";
RL Genomics 65:266-273(2000).
RN [10]
RP INTERACTION WITH INCA1.
RX PubMed=21750715; DOI=10.1371/journal.pone.0021505;
RA Zhang F., Baeumer N., Rode M., Ji P., Zhang T., Berdel W.E.,
RA Mueller-Tidow C.;
RT "The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor
RT for its antiproliferative effects.";
RL PLoS ONE 6:E21505-E21505(2011).
RN [11]
RP INTERACTION WITH FAM168B.
RX PubMed=22771904; DOI=10.1016/j.febslet.2012.06.043;
RA Mishra M., Lee S., Lin M.K., Yamashita T., Heese K.;
RT "Characterizing the neurite outgrowth inhibitory effect of Mani.";
RL FEBS Lett. 586:3018-3023(2012).
RN [12]
RP UBIQUITINATION BY SMURF2, SUBCELLULAR LOCATION, AND INTERACTION WITH
RP IL17RB.
RX PubMed=22070932; DOI=10.1016/j.imbio.2011.10.004;
RA Popova A., Kzhyshkowska J., Nurgazieva D., Goerdt S., Gratchev A.;
RT "Smurf2 regulates IL17RB by proteasomal degradation of its novel binding
RT partner DAZAP2.";
RL Immunobiology 217:321-328(2012).
CC -!- SUBUNIT: Interacts with SOX6 (By similarity). Interacts with DAZ1 and
CC DAZL. Interacts with IL17RB. May interact with FAM168B. Interacts with
CC INCA1 (PubMed:21750715). {ECO:0000250|UniProtKB:Q9DCP9,
CC ECO:0000269|PubMed:10857750, ECO:0000269|PubMed:21750715,
CC ECO:0000269|PubMed:22070932, ECO:0000269|PubMed:22771904}.
CC -!- INTERACTION:
CC Q15038; O00154-4: ACOT7; NbExp=3; IntAct=EBI-724310, EBI-12007918;
CC Q15038; P19801: AOC1; NbExp=3; IntAct=EBI-724310, EBI-12826295;
CC Q15038; Q03989: ARID5A; NbExp=8; IntAct=EBI-724310, EBI-948603;
CC Q15038; P54253: ATXN1; NbExp=2; IntAct=EBI-724310, EBI-930964;
CC Q15038; O95817: BAG3; NbExp=9; IntAct=EBI-724310, EBI-747185;
CC Q15038; Q8N1L9: BATF2; NbExp=3; IntAct=EBI-724310, EBI-742695;
CC Q15038; O14503: BHLHE40; NbExp=5; IntAct=EBI-724310, EBI-711810;
CC Q15038; Q6P1W5: C1orf94; NbExp=7; IntAct=EBI-724310, EBI-946029;
CC Q15038; Q13137: CALCOCO2; NbExp=4; IntAct=EBI-724310, EBI-739580;
CC Q15038; Q9UQM7: CAMK2A; NbExp=3; IntAct=EBI-724310, EBI-1383687;
CC Q15038; O75808: CAPN15; NbExp=3; IntAct=EBI-724310, EBI-6149008;
CC Q15038; Q8N6W0: CELF5; NbExp=6; IntAct=EBI-724310, EBI-12139335;
CC Q15038; Q96J87-2: CELF6; NbExp=3; IntAct=EBI-724310, EBI-12832044;
CC Q15038; Q96G28: CFAP36; NbExp=3; IntAct=EBI-724310, EBI-2654750;
CC Q15038; O75553: DAB1; NbExp=3; IntAct=EBI-724310, EBI-7875264;
CC Q15038; Q9NQZ3: DAZ1; NbExp=3; IntAct=EBI-724310, EBI-997955;
CC Q15038; Q15038: DAZAP2; NbExp=7; IntAct=EBI-724310, EBI-724310;
CC Q15038; Q96GG9: DCUN1D1; NbExp=9; IntAct=EBI-724310, EBI-740086;
CC Q15038; Q6ICB0: DESI1; NbExp=5; IntAct=EBI-724310, EBI-2806959;
CC Q15038; Q86UW9: DTX2; NbExp=3; IntAct=EBI-724310, EBI-740376;
CC Q15038; Q9Y6I3: EPN1; NbExp=3; IntAct=EBI-724310, EBI-713198;
CC Q15038; Q9Y6I3-3: EPN1; NbExp=3; IntAct=EBI-724310, EBI-12026538;
CC Q15038; O95208-2: EPN2; NbExp=5; IntAct=EBI-724310, EBI-12135243;
CC Q15038; I6L9I8: EPN3; NbExp=5; IntAct=EBI-724310, EBI-12866582;
CC Q15038; Q6NXG1: ESRP1; NbExp=3; IntAct=EBI-724310, EBI-10213520;
CC Q15038; Q8N9H8: EXD3; NbExp=3; IntAct=EBI-724310, EBI-750745;
CC Q15038; Q92567: FAM168A; NbExp=3; IntAct=EBI-724310, EBI-7957930;
CC Q15038; Q92567-2: FAM168A; NbExp=5; IntAct=EBI-724310, EBI-11978259;
CC Q15038; Q86UY5: FAM83A; NbExp=3; IntAct=EBI-724310, EBI-1384254;
CC Q15038; Q9NU39: FOXD4L1; NbExp=3; IntAct=EBI-724310, EBI-11320806;
CC Q15038; O75593: FOXH1; NbExp=5; IntAct=EBI-724310, EBI-1759806;
CC Q15038; Q9NZ52-2: GGA3; NbExp=3; IntAct=EBI-724310, EBI-12075758;
CC Q15038; Q13227: GPS2; NbExp=3; IntAct=EBI-724310, EBI-713355;
CC Q15038; Q9Y5R4: HEMK1; NbExp=3; IntAct=EBI-724310, EBI-10329202;
CC Q15038; Q9Y5J3: HEY1; NbExp=3; IntAct=EBI-724310, EBI-7231130;
CC Q15038; O14964: HGS; NbExp=9; IntAct=EBI-724310, EBI-740220;
CC Q15038; O00291: HIP1; NbExp=4; IntAct=EBI-724310, EBI-473886;
CC Q15038; Q96LI6: HSFY2; NbExp=3; IntAct=EBI-724310, EBI-3957665;
CC Q15038; P42858: HTT; NbExp=3; IntAct=EBI-724310, EBI-466029;
CC Q15038; Q0VD86: INCA1; NbExp=2; IntAct=EBI-724310, EBI-6509505;
CC Q15038; Q2M1V0: ISX; NbExp=3; IntAct=EBI-724310, EBI-6426064;
CC Q15038; Q9P2K6: KLHL42; NbExp=3; IntAct=EBI-724310, EBI-739890;
CC Q15038; Q3LI76: KRTAP15-1; NbExp=5; IntAct=EBI-724310, EBI-11992140;
CC Q15038; Q8IUB9: KRTAP19-1; NbExp=3; IntAct=EBI-724310, EBI-12811111;
CC Q15038; Q7Z4W3: KRTAP19-3; NbExp=6; IntAct=EBI-724310, EBI-12020132;
CC Q15038; Q3LI72: KRTAP19-5; NbExp=11; IntAct=EBI-724310, EBI-1048945;
CC Q15038; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-724310, EBI-10241353;
CC Q15038; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-724310, EBI-3957672;
CC Q15038; Q3LI64: KRTAP6-1; NbExp=8; IntAct=EBI-724310, EBI-12111050;
CC Q15038; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-724310, EBI-11962084;
CC Q15038; Q8IUC2: KRTAP8-1; NbExp=6; IntAct=EBI-724310, EBI-10261141;
CC Q15038; Q14847-2: LASP1; NbExp=5; IntAct=EBI-724310, EBI-9088686;
CC Q15038; O00182-2: LGALS9; NbExp=3; IntAct=EBI-724310, EBI-12130578;
CC Q15038; Q99732: LITAF; NbExp=5; IntAct=EBI-724310, EBI-725647;
CC Q15038; Q9Y5V3: MAGED1; NbExp=4; IntAct=EBI-724310, EBI-716006;
CC Q15038; Q8NDC0: MAPK1IP1L; NbExp=3; IntAct=EBI-724310, EBI-741424;
CC Q15038; Q8N5J2-3: MINDY1; NbExp=3; IntAct=EBI-724310, EBI-12382151;
CC Q15038; Q9H8M7: MINDY3; NbExp=3; IntAct=EBI-724310, EBI-724928;
CC Q15038; Q8N3F0: MTURN; NbExp=5; IntAct=EBI-724310, EBI-11980301;
CC Q15038; Q96EZ4: MYEOV; NbExp=3; IntAct=EBI-724310, EBI-12260130;
CC Q15038; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-724310, EBI-5662487;
CC Q15038; Q96HR8: NAF1; NbExp=3; IntAct=EBI-724310, EBI-2515597;
CC Q15038; Q96PU5: NEDD4L; NbExp=3; IntAct=EBI-724310, EBI-717962;
CC Q15038; Q96PU5-2: NEDD4L; NbExp=3; IntAct=EBI-724310, EBI-6955201;
CC Q15038; Q96CV9: OPTN; NbExp=6; IntAct=EBI-724310, EBI-748974;
CC Q15038; Q96DC9: OTUB2; NbExp=5; IntAct=EBI-724310, EBI-746259;
CC Q15038; Q6GQQ9: OTUD7B; NbExp=3; IntAct=EBI-724310, EBI-527784;
CC Q15038; Q96BN8: OTULIN; NbExp=6; IntAct=EBI-724310, EBI-750730;
CC Q15038; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-724310, EBI-11022007;
CC Q15038; Q8N165: PDIK1L; NbExp=3; IntAct=EBI-724310, EBI-6423298;
CC Q15038; Q9UBV8: PEF1; NbExp=6; IntAct=EBI-724310, EBI-724639;
CC Q15038; Q99697-2: PITX2; NbExp=3; IntAct=EBI-724310, EBI-12138495;
CC Q15038; Q96CS7: PLEKHB2; NbExp=11; IntAct=EBI-724310, EBI-373552;
CC Q15038; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-724310, EBI-742388;
CC Q15038; O15162: PLSCR1; NbExp=4; IntAct=EBI-724310, EBI-740019;
CC Q15038; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-724310, EBI-769257;
CC Q15038; Q7Z3K3: POGZ; NbExp=8; IntAct=EBI-724310, EBI-1389308;
CC Q15038; Q9UNA4: POLI; NbExp=3; IntAct=EBI-724310, EBI-741774;
CC Q15038; O75360: PROP1; NbExp=3; IntAct=EBI-724310, EBI-9027467;
CC Q15038; Q9NZ81: PRR13; NbExp=3; IntAct=EBI-724310, EBI-740924;
CC Q15038; P86479: PRR20C; NbExp=4; IntAct=EBI-724310, EBI-10172814;
CC Q15038; P86480: PRR20D; NbExp=5; IntAct=EBI-724310, EBI-12754095;
CC Q15038; Q9NV39: PRR34; NbExp=3; IntAct=EBI-724310, EBI-11959565;
CC Q15038; Q9UJ41: RABGEF1; NbExp=3; IntAct=EBI-724310, EBI-913954;
CC Q15038; Q9UJ41-4: RABGEF1; NbExp=6; IntAct=EBI-724310, EBI-14093916;
CC Q15038; Q9NS91: RAD18; NbExp=3; IntAct=EBI-724310, EBI-2339393;
CC Q15038; P54725: RAD23A; NbExp=3; IntAct=EBI-724310, EBI-746453;
CC Q15038; Q9BTL3: RAMAC; NbExp=3; IntAct=EBI-724310, EBI-744023;
CC Q15038; Q9NWB1-5: RBFOX1; NbExp=4; IntAct=EBI-724310, EBI-12123390;
CC Q15038; O43251: RBFOX2; NbExp=4; IntAct=EBI-724310, EBI-746056;
CC Q15038; O43251-10: RBFOX2; NbExp=4; IntAct=EBI-724310, EBI-11963050;
CC Q15038; Q9BX46-2: RBM24; NbExp=3; IntAct=EBI-724310, EBI-12224445;
CC Q15038; Q6ZSC3: RBM43; NbExp=3; IntAct=EBI-724310, EBI-2880658;
CC Q15038; Q93062: RBPMS; NbExp=6; IntAct=EBI-724310, EBI-740322;
CC Q15038; Q93062-3: RBPMS; NbExp=7; IntAct=EBI-724310, EBI-740343;
CC Q15038; Q9BQY4: RHOXF2; NbExp=12; IntAct=EBI-724310, EBI-372094;
CC Q15038; Q9Y4L5: RNF115; NbExp=5; IntAct=EBI-724310, EBI-2129242;
CC Q15038; Q9H0X6: RNF208; NbExp=10; IntAct=EBI-724310, EBI-751555;
CC Q15038; Q7L0R7: RNF44; NbExp=3; IntAct=EBI-724310, EBI-2845060;
CC Q15038; A1L4F5: ROR2; NbExp=3; IntAct=EBI-724310, EBI-10172778;
CC Q15038; Q01974: ROR2; NbExp=8; IntAct=EBI-724310, EBI-6422642;
CC Q15038; P62979: RPS27A; NbExp=9; IntAct=EBI-724310, EBI-357375;
CC Q15038; Q8WU79: SMAP2; NbExp=6; IntAct=EBI-724310, EBI-2822515;
CC Q15038; P09234: SNRPC; NbExp=3; IntAct=EBI-724310, EBI-766589;
CC Q15038; P56693: SOX10; NbExp=3; IntAct=EBI-724310, EBI-1167533;
CC Q15038; Q13501: SQSTM1; NbExp=4; IntAct=EBI-724310, EBI-307104;
CC Q15038; O75886: STAM2; NbExp=7; IntAct=EBI-724310, EBI-373258;
CC Q15038; Q86VP1: TAX1BP1; NbExp=6; IntAct=EBI-724310, EBI-529518;
CC Q15038; O95947: TBX6; NbExp=3; IntAct=EBI-724310, EBI-2824328;
CC Q15038; Q96A09: TENT5B; NbExp=7; IntAct=EBI-724310, EBI-752030;
CC Q15038; Q96LM6: TEX37; NbExp=9; IntAct=EBI-724310, EBI-743976;
CC Q15038; Q92734: TFG; NbExp=5; IntAct=EBI-724310, EBI-357061;
CC Q15038; Q01085-2: TIAL1; NbExp=5; IntAct=EBI-724310, EBI-11064654;
CC Q15038; Q04724: TLE1; NbExp=3; IntAct=EBI-724310, EBI-711424;
CC Q15038; Q08117-2: TLE5; NbExp=3; IntAct=EBI-724310, EBI-11741437;
CC Q15038; Q15025: TNIP1; NbExp=3; IntAct=EBI-724310, EBI-357849;
CC Q15038; Q96KP6: TNIP3; NbExp=9; IntAct=EBI-724310, EBI-2509913;
CC Q15038; Q6FIE9: TOLLIP; NbExp=3; IntAct=EBI-724310, EBI-10249783;
CC Q15038; Q9H0E2: TOLLIP; NbExp=11; IntAct=EBI-724310, EBI-74615;
CC Q15038; O60784-2: TOM1; NbExp=3; IntAct=EBI-724310, EBI-12117154;
CC Q15038; P62987: UBA52; NbExp=7; IntAct=EBI-724310, EBI-357304;
CC Q15038; Q9BSL1: UBAC1; NbExp=7; IntAct=EBI-724310, EBI-749370;
CC Q15038; Q5T6F2: UBAP2; NbExp=3; IntAct=EBI-724310, EBI-2514383;
CC Q15038; P57075: UBASH3A; NbExp=4; IntAct=EBI-724310, EBI-2105393;
CC Q15038; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-724310, EBI-7353612;
CC Q15038; Q8TF42: UBASH3B; NbExp=6; IntAct=EBI-724310, EBI-1380492;
CC Q15038; P0CG47: UBB; NbExp=7; IntAct=EBI-724310, EBI-413034;
CC Q15038; Q5U5U6: UBB; NbExp=3; IntAct=EBI-724310, EBI-1642104;
CC Q15038; P0CG48: UBC; NbExp=6; IntAct=EBI-724310, EBI-3390054;
CC Q15038; Q96C32: UBC; NbExp=4; IntAct=EBI-724310, EBI-745483;
CC Q15038; Q9Y2X8: UBE2D4; NbExp=3; IntAct=EBI-724310, EBI-745527;
CC Q15038; Q96LR5: UBE2E2; NbExp=3; IntAct=EBI-724310, EBI-2129763;
CC Q15038; Q969T4: UBE2E3; NbExp=3; IntAct=EBI-724310, EBI-348496;
CC Q15038; Q13404: UBE2V1; NbExp=3; IntAct=EBI-724310, EBI-1050671;
CC Q15038; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-724310, EBI-741480;
CC Q15038; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-724310, EBI-947187;
CC Q15038; Q9BZV1: UBXN6; NbExp=5; IntAct=EBI-724310, EBI-1993899;
CC Q15038; O94888: UBXN7; NbExp=3; IntAct=EBI-724310, EBI-1993627;
CC Q15038; Q92995: USP13; NbExp=3; IntAct=EBI-724310, EBI-714351;
CC Q15038; P45974: USP5; NbExp=3; IntAct=EBI-724310, EBI-741277;
CC Q15038; O95231: VENTX; NbExp=3; IntAct=EBI-724310, EBI-10191303;
CC Q15038; Q14119: VEZF1; NbExp=3; IntAct=EBI-724310, EBI-11980193;
CC Q15038; Q6RSH7: VHLL; NbExp=8; IntAct=EBI-724310, EBI-10254232;
CC Q15038; A5D8V6: VPS37C; NbExp=6; IntAct=EBI-724310, EBI-2559305;
CC Q15038; Q9NZC7-5: WWOX; NbExp=6; IntAct=EBI-724310, EBI-12040603;
CC Q15038; Q5VVQ6: YOD1; NbExp=7; IntAct=EBI-724310, EBI-2510804;
CC Q15038; A0A0C4DGF1: ZBTB32; NbExp=5; IntAct=EBI-724310, EBI-10188476;
CC Q15038; Q96K80: ZC3H10; NbExp=7; IntAct=EBI-724310, EBI-742550;
CC Q15038; Q8N6M9: ZFAND2A; NbExp=3; IntAct=EBI-724310, EBI-3921109;
CC Q15038; Q8WV99: ZFAND2B; NbExp=10; IntAct=EBI-724310, EBI-747823;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly nuclear in
CC macrophages, stimulation of IL17RB with its ligand IL17E induces
CC accumulation in the cytoplasm.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q15038-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q15038-2; Sequence=VSP_042773;
CC Name=6;
CC IsoId=Q15038-6; Sequence=VSP_055181;
CC Name=3;
CC IsoId=Q15038-3; Sequence=VSP_045679;
CC Name=4;
CC IsoId=Q15038-4; Sequence=VSP_045678;
CC Name=5;
CC IsoId=Q15038-5; Sequence=VSP_046764;
CC -!- TISSUE SPECIFICITY: Widely expressed. Expressed in spleen, thymus,
CC prostate, testis, ovary, small intestine, colon and leukocytes. Down-
CC regulated in multiple myeloma. {ECO:0000269|PubMed:10857750}.
CC -!- PTM: Ubiquitinated by SMURF2, leading to proteasomal degradation.
CC {ECO:0000269|PubMed:22070932}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA06545.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY430097; AAR11454.1; -; mRNA.
DR EMBL; BU662353; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; D31767; BAA06545.2; ALT_INIT; mRNA.
DR EMBL; BX441137; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK095963; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK290119; BAF82808.1; -; mRNA.
DR EMBL; AK293330; BAG56846.1; -; mRNA.
DR EMBL; AK303828; BAG64775.1; -; mRNA.
DR EMBL; AC046135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC139768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471111; EAW58181.1; -; Genomic_DNA.
DR EMBL; BC002334; AAH02334.1; -; mRNA.
DR EMBL; BC007900; AAH07900.1; -; mRNA.
DR CCDS; CCDS44884.1; -. [Q15038-2]
DR CCDS; CCDS44885.1; -. [Q15038-5]
DR CCDS; CCDS44886.1; -. [Q15038-6]
DR CCDS; CCDS44887.1; -. [Q15038-3]
DR CCDS; CCDS44888.1; -. [Q15038-4]
DR CCDS; CCDS8809.1; -. [Q15038-1]
DR RefSeq; NP_001129736.1; NM_001136264.1. [Q15038-6]
DR RefSeq; NP_001129738.1; NM_001136266.1. [Q15038-5]
DR RefSeq; NP_001129739.1; NM_001136267.1. [Q15038-3]
DR RefSeq; NP_001129740.1; NM_001136268.1. [Q15038-4]
DR RefSeq; NP_001129741.1; NM_001136269.1. [Q15038-2]
DR RefSeq; NP_055579.1; NM_014764.3. [Q15038-1]
DR AlphaFoldDB; Q15038; -.
DR BioGRID; 115143; 192.
DR IntAct; Q15038; 189.
DR MINT; Q15038; -.
DR STRING; 9606.ENSP00000448051; -.
DR MoonDB; Q15038; Predicted.
DR iPTMnet; Q15038; -.
DR PhosphoSitePlus; Q15038; -.
DR BioMuta; DAZAP2; -.
DR DMDM; 44887865; -.
DR EPD; Q15038; -.
DR jPOST; Q15038; -.
DR MassIVE; Q15038; -.
DR MaxQB; Q15038; -.
DR PaxDb; Q15038; -.
DR PeptideAtlas; Q15038; -.
DR PRIDE; Q15038; -.
DR ProteomicsDB; 11080; -.
DR ProteomicsDB; 19140; -.
DR ProteomicsDB; 60386; -. [Q15038-1]
DR ProteomicsDB; 60387; -. [Q15038-2]
DR ProteomicsDB; 9296; -.
DR Antibodypedia; 26360; 113 antibodies from 22 providers.
DR DNASU; 9802; -.
DR Ensembl; ENST00000412716.8; ENSP00000394699.2; ENSG00000183283.16. [Q15038-1]
DR Ensembl; ENST00000425012.6; ENSP00000408251.2; ENSG00000183283.16. [Q15038-2]
DR Ensembl; ENST00000439799.6; ENSP00000398804.2; ENSG00000183283.16. [Q15038-4]
DR Ensembl; ENST00000449723.7; ENSP00000412812.2; ENSG00000183283.16. [Q15038-6]
DR Ensembl; ENST00000549555.5; ENSP00000448051.1; ENSG00000183283.16. [Q15038-5]
DR Ensembl; ENST00000549732.6; ENSP00000446554.2; ENSG00000183283.16. [Q15038-3]
DR GeneID; 9802; -.
DR KEGG; hsa:9802; -.
DR MANE-Select; ENST00000412716.8; ENSP00000394699.2; NM_014764.4; NP_055579.1.
DR UCSC; uc001ryb.4; human. [Q15038-1]
DR CTD; 9802; -.
DR DisGeNET; 9802; -.
DR GeneCards; DAZAP2; -.
DR HGNC; HGNC:2684; DAZAP2.
DR HPA; ENSG00000183283; Low tissue specificity.
DR MIM; 607431; gene.
DR neXtProt; NX_Q15038; -.
DR OpenTargets; ENSG00000183283; -.
DR PharmGKB; PA27154; -.
DR VEuPathDB; HostDB:ENSG00000183283; -.
DR eggNOG; ENOG502QTNQ; Eukaryota.
DR GeneTree; ENSGT00390000000685; -.
DR HOGENOM; CLU_1325998_0_0_1; -.
DR InParanoid; Q15038; -.
DR OMA; IYQPRYM; -.
DR OrthoDB; 1175298at2759; -.
DR PhylomeDB; Q15038; -.
DR TreeFam; TF329672; -.
DR PathwayCommons; Q15038; -.
DR SignaLink; Q15038; -.
DR BioGRID-ORCS; 9802; 19 hits in 1078 CRISPR screens.
DR ChiTaRS; DAZAP2; human.
DR GeneWiki; DAZAP2; -.
DR GenomeRNAi; 9802; -.
DR Pharos; Q15038; Tbio.
DR PRO; PR:Q15038; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q15038; protein.
DR Bgee; ENSG00000183283; Expressed in amniotic fluid and 203 other tissues.
DR ExpressionAtlas; Q15038; baseline and differential.
DR Genevisible; Q15038; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IDA:HPA.
DR GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IEA:Ensembl.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:Ensembl.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0050699; F:WW domain binding; IPI:UniProtKB.
DR InterPro; IPR022730; DAZ_assoc-2.
DR PANTHER; PTHR31638; PTHR31638; 1.
DR Pfam; PF11029; DAZAP2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..168
FT /note="DAZ-associated protein 2"
FT /id="PRO_0000079788"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 45..126
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_045678"
FT VAR_SEQ 45..76
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_045679"
FT VAR_SEQ 65..86
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000305"
FT /id="VSP_055181"
FT VAR_SEQ 101..168
FT /note="GSTVLVEGGYDAGARFGAGATAGNIPPPPPGCPPNAAQLAVMQGANVLVTQR
FT KGNFFMGGSDGGYTIW -> ASTSWMPSQCCSACSHAGSQRPRNSAEGELLHGWFRWWL
FT HHLVRNQGHLCAGKDITYLQHFSQCNCFSHINLKLQFRHMLLGCLSGAQTFRHFSNLIR
FT NHVMVAVPP (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_046764"
FT VAR_SEQ 127..168
FT /note="PPPPGCPPNAAQLAVMQGANVLVTQRKGNFFMGGSDGGYTIW -> VKEDQD
FT HDREQGEEDNGDNNLERRGKM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042773"
FT VARIANT 102
FT /note="S -> A (in dbSNP:rs57917280)"
FT /id="VAR_061639"
FT CONFLICT 29
FT /note="L -> P (in Ref. 5; BAG64775)"
FT /evidence="ECO:0000305"
FT CONFLICT 47
FT /note="R -> S (in Ref. 1; AAR11454)"
FT /evidence="ECO:0000305"
FT CONFLICT 90
FT /note="A -> V (in Ref. 2; BU662353)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 168 AA; 17319 MW; 49F1B6D281E24AAC CRC64;
MNSKGQYPTQ PTYPVQPPGN PVYPQTLHLP QAPPYTDAPP AYSELYRPSF VHPGAATVPT
MSAAFPGASL YLPMAQSVAV GPLGSTIPMA YYPVGPIYPP GSTVLVEGGY DAGARFGAGA
TAGNIPPPPP GCPPNAAQLA VMQGANVLVT QRKGNFFMGG SDGGYTIW
