ID   DAZP2_MACFA             Reviewed;         168 AA.
AC   Q4R5H7;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=DAZ-associated protein 2;
DE   AltName: Full=Deleted in azoospermia-associated protein 2;
GN   Name=DAZAP2; ORFNames=QflA-14287;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Frontal cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Interacts with DAZ1 and DAZL. Interacts with SOX6. Interacts
CC       with IL17RB. May interact with FAM168B. Interacts with INCA1.
CC       {ECO:0000250|UniProtKB:Q15038, ECO:0000250|UniProtKB:Q9DCP9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Predominantly nuclear in macrophages, stimulation of IL17RB with
CC       its ligand IL17E induces accumulation in the cytoplasm. {ECO:0000250}.
CC   -!- PTM: Ubiquitinated by SMURF2, leading to proteasomal degradation.
CC       {ECO:0000250}.
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DR   EMBL; AB169566; BAE01648.1; -; mRNA.
DR   RefSeq; NP_001271055.1; NM_001284126.1.
DR   AlphaFoldDB; Q4R5H7; -.
DR   STRING; 9541.XP_005570938.1; -.
DR   Ensembl; ENSMFAT00000021034; ENSMFAP00000009016; ENSMFAG00000001009.
DR   GeneID; 101926026; -.
DR   CTD; 9802; -.
DR   eggNOG; ENOG502QTNQ; Eukaryota.
DR   GeneTree; ENSGT00390000000685; -.
DR   Proteomes; UP000233100; Chromosome 11.
DR   Bgee; ENSMFAG00000001009; Expressed in spleen and 13 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR022730; DAZ_assoc-2.
DR   PANTHER; PTHR31638; PTHR31638; 1.
DR   Pfam; PF11029; DAZAP2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Ubl conjugation.
FT   CHAIN           1..168
FT                   /note="DAZ-associated protein 2"
FT                   /id="PRO_0000285818"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..25
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   168 AA;  17349 MW;  49E0E39690B70EAC CRC64;
     MNSKGQYPTQ PTYPVQPPGN PVYPQTLHLP QAPPYTDAPP AYSELYRPSF VHPGAATVPT
     MSAAFPGASL YLPMAQSVAV GPLGSTIPMA YYPVSPIYPP GSTVLVEGGY DAGARFGAGA
     TAGNIPPPPP GCPPNAAQLA VMQGANVLVT QRKGNFFMGG SDGGYTIW