ID   DAZP2_RAT               Reviewed;         108 AA.
AC   P60486;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=DAZ-associated protein 2;
DE   AltName: Full=Deleted in azoospermia-associated protein 2;
GN   Name=Dazap2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Interacts with DAZ1 and DAZL. Interacts with SOX6. Interacts
CC       with IL17RB. May interact with FAM168B. Interacts with INCA1.
CC       {ECO:0000250|UniProtKB:Q15038, ECO:0000250|UniProtKB:Q9DCP9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Predominantly nuclear in macrophages, stimulation of IL17RB with
CC       its ligand IL17E induces accumulation in the cytoplasm. {ECO:0000250}.
CC   -!- PTM: Ubiquitinated by SMURF2, leading to proteasomal degradation.
CC       {ECO:0000250}.
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DR   EMBL; BC062052; AAH62052.1; -; mRNA.
DR   RefSeq; NP_001013125.1; NM_001013107.1.
DR   AlphaFoldDB; P60486; -.
DR   STRING; 10116.ENSRNOP00000006239; -.
DR   PaxDb; P60486; -.
DR   GeneID; 300235; -.
DR   KEGG; rno:300235; -.
DR   CTD; 9802; -.
DR   RGD; 1307407; Dazap2.
DR   eggNOG; ENOG502QTNQ; Eukaryota.
DR   HOGENOM; CLU_135110_0_0_1; -.
DR   InParanoid; P60486; -.
DR   PhylomeDB; P60486; -.
DR   PRO; PR:P60486; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; P60486; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; ISO:RGD.
DR   GO; GO:0043539; F:protein serine/threonine kinase activator activity; ISO:RGD.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; ISO:RGD.
DR   GO; GO:0050699; F:WW domain binding; ISO:RGD.
DR   GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; ISO:RGD.
DR   InterPro; IPR022730; DAZ_assoc-2.
DR   PANTHER; PTHR31638; PTHR31638; 1.
DR   Pfam; PF11029; DAZAP2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Ubl conjugation.
FT   CHAIN           1..108
FT                   /note="DAZ-associated protein 2"
FT                   /id="PRO_0000079790"
SQ   SEQUENCE   108 AA;  10775 MW;  F197E40EA23A925D CRC64;
     MSAAFPGASL YLPMAQSVAV GPLGSTIPMA YYPVGPIYPP GSAVLVEGGY DAGARFGAGA
     TTGSIPPPPP GCPPNAAQLA VMQGANVLVT QRKGNFFMGG SDGGYTIW