ID   DB108_HUMAN             Reviewed;          73 AA.
AC   A8MXU0;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Putative beta-defensin 108A;
DE   AltName: Full=Defensin, beta 108A {ECO:0000312|HGNC:HGNC:18089};
DE   AltName: Full=Defensin, beta 108C {ECO:0000312|HGNC:HGNC:30847};
DE   AltName: Full=Putative beta-defensin 108B pseudogene 1/2;
DE   Flags: Precursor;
GN   Name=DEFB108A {ECO:0000312|HGNC:HGNC:18089}; Synonyms=DEFB108P1;
GN   and
GN   Name=DEFB108C {ECO:0000312|HGNC:HGNC:30847}; Synonyms=DEFB108P2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-59.
RX   PubMed=12734011; DOI=10.1186/gb-2003-4-5-r31;
RA   Semple C.A.M., Rolfe M., Dorin J.R.;
RT   "Duplication and selection in the evolution of primate beta-defensin
RT   genes.";
RL   Genome Biol. 4:R31.1-R31.11(2003).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC130360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF540980; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; A8MXU0; -.
DR   SMR; A8MXU0; -.
DR   BioMuta; HGNC:18089; -.
DR   PRIDE; A8MXU0; -.
DR   GeneCards; DEFB108A; -.
DR   GeneCards; DEFB108C; -.
DR   HGNC; HGNC:18089; DEFB108A.
DR   HGNC; HGNC:30847; DEFB108C.
DR   neXtProt; NX_A8MXU0; -.
DR   InParanoid; A8MXU0; -.
DR   PhylomeDB; A8MXU0; -.
DR   PathwayCommons; A8MXU0; -.
DR   Reactome; R-HSA-1461957; Beta defensins.
DR   Pharos; A8MXU0; Tdark.
DR   PRO; PR:A8MXU0; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; A8MXU0; protein.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   5: Uncertain;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..73
FT                   /note="Putative beta-defensin 108A"
FT                   /id="PRO_0000341263"
FT   DISULFID        28..55
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..49
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..56
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   73 AA;  8390 MW;  ED4C8C652A4C7FDA CRC64;
     MRIAVLFFTI FFFMSQVLPA KGKFKEICER PNGSCRDFCL ETEIHVGRCL NSRPCCLPLG
     HQPRIESTTP KKD