DB110_HUMAN
ID DB110_HUMAN Reviewed; 67 AA.
AC Q30KQ9; Q30KR0;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Beta-defensin 110;
DE AltName: Full=Beta-defensin 10;
DE Short=DEFB-10;
DE AltName: Full=Beta-defensin 11;
DE Short=DEFB-11;
DE AltName: Full=Beta-defensin 111;
DE AltName: Full=Defensin, beta 110;
DE AltName: Full=Defensin, beta 111;
DE Flags: Precursor;
GN Name=DEFB110; Synonyms=DEFB10, DEFB11, DEFB111;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q30KQ9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q30KQ9-2; Sequence=VSP_038146;
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; DQ012014; AAY59750.1; -; mRNA.
DR EMBL; DQ012015; AAY59751.1; -; mRNA.
DR EMBL; AL138879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS34475.1; -. [Q30KQ9-1]
DR CCDS; CCDS43473.1; -. [Q30KQ9-2]
DR RefSeq; NP_001032586.1; NM_001037497.1. [Q30KQ9-1]
DR RefSeq; NP_001032817.1; NM_001037728.2. [Q30KQ9-2]
DR AlphaFoldDB; Q30KQ9; -.
DR SMR; Q30KQ9; -.
DR BioGRID; 128838; 16.
DR STRING; 9606.ENSP00000360190; -.
DR iPTMnet; Q30KQ9; -.
DR BioMuta; DEFB110; -.
DR DMDM; 84028871; -.
DR MassIVE; Q30KQ9; -.
DR PaxDb; Q30KQ9; -.
DR PRIDE; Q30KQ9; -.
DR Antibodypedia; 57764; 12 antibodies from 4 providers.
DR DNASU; 245913; -.
DR Ensembl; ENST00000371148.3; ENSP00000360190.2; ENSG00000203970.4. [Q30KQ9-1]
DR Ensembl; ENST00000393660.2; ENSP00000377270.2; ENSG00000203970.4. [Q30KQ9-2]
DR GeneID; 245913; -.
DR KEGG; hsa:245913; -.
DR MANE-Select; ENST00000371148.3; ENSP00000360190.2; NM_001037497.2; NP_001032586.1.
DR UCSC; uc003pac.3; human. [Q30KQ9-1]
DR CTD; 245913; -.
DR GeneCards; DEFB110; -.
DR HGNC; HGNC:18091; DEFB110.
DR HPA; ENSG00000203970; Tissue enriched (epididymis).
DR neXtProt; NX_Q30KQ9; -.
DR OpenTargets; ENSG00000203970; -.
DR PharmGKB; PA38487; -.
DR VEuPathDB; HostDB:ENSG00000203970; -.
DR eggNOG; ENOG502TGN0; Eukaryota.
DR GeneTree; ENSGT00390000006761; -.
DR HOGENOM; CLU_187020_0_0_1; -.
DR InParanoid; Q30KQ9; -.
DR OMA; EGNGRCK; -.
DR OrthoDB; 1610592at2759; -.
DR PhylomeDB; Q30KQ9; -.
DR PathwayCommons; Q30KQ9; -.
DR Reactome; R-HSA-1461957; Beta defensins.
DR Reactome; R-HSA-1461973; Defensins.
DR BioGRID-ORCS; 245913; 5 hits in 991 CRISPR screens.
DR GenomeRNAi; 245913; -.
DR Pharos; Q30KQ9; Tdark.
DR PRO; PR:Q30KQ9; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q30KQ9; protein.
DR Bgee; ENSG00000203970; Expressed in cell and 36 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Antibiotic; Antimicrobial; Defensin; Disulfide bond;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..67
FT /note="Beta-defensin 110"
FT /id="PRO_0000045336"
FT DISULFID 35..63
FT /evidence="ECO:0000250"
FT DISULFID 42..56
FT /evidence="ECO:0000250"
FT DISULFID 46..64
FT /evidence="ECO:0000250"
FT VAR_SEQ 20..67
FT /note="KKKYPEYGSLDLRRECRIGNGQCKNQCHENEIRIAYCIRPGTHCCLQQ ->
FT RSNFEPKYRFERCEKVRGICKTFCDDVEYDYGYCIKWRSQCCV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16033865"
FT /id="VSP_038146"
SQ SEQUENCE 67 AA; 8001 MW; 923DBCA99BC9B3E9 CRC64;
MKIQLFFFIL HFWVTILPAK KKYPEYGSLD LRRECRIGNG QCKNQCHENE IRIAYCIRPG
THCCLQQ
