DB112_HUMAN
ID DB112_HUMAN Reviewed; 113 AA.
AC Q30KQ8; Q8NET0;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Beta-defensin 112;
DE AltName: Full=Beta-defensin 12;
DE Short=DEFB-12;
DE AltName: Full=Defensin, beta 112;
DE Flags: Precursor;
GN Name=DEFB112; Synonyms=DEFB12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 53-73.
RX PubMed=11854508; DOI=10.1073/pnas.042692699;
RA Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P.,
RA Welsh M.J., Casavant T.L., McCray P.B. Jr.;
RT "Discovery of five conserved beta-defensin gene clusters using a
RT computational search strategy.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- INTERACTION:
CC Q30KQ8; O75031: HSF2BP; NbExp=3; IntAct=EBI-17470374, EBI-7116203;
CC Q30KQ8; B2RUY7: VWC2L; NbExp=3; IntAct=EBI-17470374, EBI-11747707;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; DQ012016; AAY59752.1; -; mRNA.
DR EMBL; AY122469; AAM93911.1; -; mRNA.
DR RefSeq; NP_001032587.1; NM_001037498.1.
DR AlphaFoldDB; Q30KQ8; -.
DR SMR; Q30KQ8; -.
DR BioGRID; 128840; 17.
DR IntAct; Q30KQ8; 2.
DR STRING; 9606.ENSP00000319126; -.
DR BioMuta; DEFB112; -.
DR DMDM; 84028873; -.
DR MassIVE; Q30KQ8; -.
DR PaxDb; Q30KQ8; -.
DR PeptideAtlas; Q30KQ8; -.
DR PRIDE; Q30KQ8; -.
DR ProteomicsDB; 61580; -.
DR DNASU; 245915; -.
DR UCSC; uc011dws.2; human.
DR GeneCards; DEFB112; -.
DR HGNC; HGNC:18093; DEFB112.
DR neXtProt; NX_Q30KQ8; -.
DR PharmGKB; PA38489; -.
DR eggNOG; ENOG502TDZN; Eukaryota.
DR HOGENOM; CLU_176668_0_0_1; -.
DR InParanoid; Q30KQ8; -.
DR OrthoDB; 1486606at2759; -.
DR PhylomeDB; Q30KQ8; -.
DR TreeFam; TF353195; -.
DR PathwayCommons; Q30KQ8; -.
DR Reactome; R-HSA-1461957; Beta defensins.
DR Reactome; R-HSA-1461973; Defensins.
DR SignaLink; Q30KQ8; -.
DR BioGRID-ORCS; 245915; 12 hits in 1032 CRISPR screens.
DR GenomeRNAi; 245915; -.
DR Pharos; Q30KQ8; Tdark.
DR PRO; PR:Q30KQ8; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q30KQ8; protein.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..?
FT /evidence="ECO:0000255"
FT CHAIN ?..113
FT /note="Beta-defensin 112"
FT /id="PRO_0000045338"
FT DISULFID 54..82
FT /evidence="ECO:0000250"
FT DISULFID 61..75
FT /evidence="ECO:0000250"
FT DISULFID 65..83
FT /evidence="ECO:0000250"
SQ SEQUENCE 113 AA; 12991 MW; 53617991C2160524 CRC64;
MKLLTTICRL KLEKMYSKTN TSSTIFEKAR HGTEKISTAR SEGHHITFSR WKSCTAIGGR
CKNQCDDSEF RISYCARPTT HCCVTECDPT DPNNWIPKDS VGTQEWYPKD SRH
