DB115_HUMAN
ID DB115_HUMAN Reviewed; 88 AA.
AC Q30KQ5;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Beta-defensin 115;
DE AltName: Full=Beta-defensin 15;
DE Short=DEFB-15;
DE AltName: Full=Defensin, beta 115;
DE Flags: Precursor;
GN Name=DEFB115; Synonyms=DEFB15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- INTERACTION:
CC Q30KQ5; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-12253292, EBI-741480;
CC Q30KQ5; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-12253292, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; DQ012019; AAY59755.1; -; mRNA.
DR EMBL; AL121723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS42859.1; -.
DR RefSeq; NP_001032819.1; NM_001037730.1.
DR AlphaFoldDB; Q30KQ5; -.
DR SMR; Q30KQ5; -.
DR BioGRID; 128843; 4.
DR IntAct; Q30KQ5; 2.
DR STRING; 9606.ENSP00000383398; -.
DR iPTMnet; Q30KQ5; -.
DR PhosphoSitePlus; Q30KQ5; -.
DR BioMuta; DEFB115; -.
DR DMDM; 84028877; -.
DR PaxDb; Q30KQ5; -.
DR PRIDE; Q30KQ5; -.
DR Antibodypedia; 54286; 9 antibodies from 7 providers.
DR DNASU; 245929; -.
DR Ensembl; ENST00000400552.1; ENSP00000383398.1; ENSG00000215547.1.
DR GeneID; 245929; -.
DR KEGG; hsa:245929; -.
DR MANE-Select; ENST00000400552.1; ENSP00000383398.1; NM_001037730.1; NP_001032819.1.
DR UCSC; uc002wvp.1; human.
DR CTD; 245929; -.
DR GeneCards; DEFB115; -.
DR HGNC; HGNC:18096; DEFB115.
DR HPA; ENSG00000215547; Tissue enhanced (epididymis).
DR neXtProt; NX_Q30KQ5; -.
DR PharmGKB; PA38492; -.
DR VEuPathDB; HostDB:ENSG00000215547; -.
DR eggNOG; ENOG502TD4T; Eukaryota.
DR GeneTree; ENSGT00400000023200; -.
DR HOGENOM; CLU_181906_1_1_1; -.
DR InParanoid; Q30KQ5; -.
DR OMA; CRNNERE; -.
DR OrthoDB; 1548404at2759; -.
DR PhylomeDB; Q30KQ5; -.
DR PathwayCommons; Q30KQ5; -.
DR Reactome; R-HSA-1461957; Beta defensins.
DR Reactome; R-HSA-1461973; Defensins.
DR SignaLink; Q30KQ5; -.
DR BioGRID-ORCS; 245929; 12 hits in 1027 CRISPR screens.
DR GenomeRNAi; 245929; -.
DR Pharos; Q30KQ5; Tdark.
DR PRO; PR:Q30KQ5; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q30KQ5; protein.
DR Bgee; ENSG00000215547; Expressed in cell and 29 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..88
FT /note="Beta-defensin 115"
FT /id="PRO_0000045343"
FT DISULFID 38..65
FT /evidence="ECO:0000250"
FT DISULFID 45..59
FT /evidence="ECO:0000250"
FT DISULFID 49..66
FT /evidence="ECO:0000250"
SQ SEQUENCE 88 AA; 10071 MW; 9E4437B69A9121CC CRC64;
MLPDHFSPLS GDIKLSVLAL VVLVVLAQTA PDGWIRRCYY GTGRCRKSCK EIERKKEKCG
EKHICCVPKE KDKLSHIHDQ KETSELYI
