DB116_HUMAN
ID DB116_HUMAN Reviewed; 102 AA.
AC Q30KQ4;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Beta-defensin 116;
DE AltName: Full=Beta-defensin 16;
DE Short=DEFB-16;
DE AltName: Full=Defensin, beta 116;
DE Flags: Precursor;
GN Name=DEFB116; Synonyms=DEFB16;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; DQ012020; AAY59756.1; -; mRNA.
DR EMBL; AL031650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS42860.1; -.
DR RefSeq; NP_001032820.1; NM_001037731.1.
DR AlphaFoldDB; Q30KQ4; -.
DR SMR; Q30KQ4; -.
DR BioGRID; 128844; 7.
DR IntAct; Q30KQ4; 1.
DR STRING; 9606.ENSP00000383396; -.
DR iPTMnet; Q30KQ4; -.
DR PhosphoSitePlus; Q30KQ4; -.
DR BioMuta; DEFB116; -.
DR DMDM; 84028878; -.
DR PaxDb; Q30KQ4; -.
DR PeptideAtlas; Q30KQ4; -.
DR PRIDE; Q30KQ4; -.
DR Antibodypedia; 49711; 8 antibodies from 6 providers.
DR DNASU; 245930; -.
DR Ensembl; ENST00000400549.1; ENSP00000383396.1; ENSG00000215545.1.
DR GeneID; 245930; -.
DR KEGG; hsa:245930; -.
DR MANE-Select; ENST00000400549.1; ENSP00000383396.1; NM_001037731.1; NP_001032820.1.
DR UCSC; uc010ztm.2; human.
DR CTD; 245930; -.
DR DisGeNET; 245930; -.
DR GeneCards; DEFB116; -.
DR HGNC; HGNC:18097; DEFB116.
DR HPA; ENSG00000215545; Not detected.
DR neXtProt; NX_Q30KQ4; -.
DR PharmGKB; PA38493; -.
DR VEuPathDB; HostDB:ENSG00000215545; -.
DR eggNOG; ENOG502TF8H; Eukaryota.
DR GeneTree; ENSGT00390000001502; -.
DR HOGENOM; CLU_2482789_0_0_1; -.
DR InParanoid; Q30KQ4; -.
DR OMA; NACRKYE; -.
DR OrthoDB; 1588126at2759; -.
DR PhylomeDB; Q30KQ4; -.
DR PathwayCommons; Q30KQ4; -.
DR Reactome; R-HSA-1461957; Beta defensins.
DR Reactome; R-HSA-1461973; Defensins.
DR SignaLink; Q30KQ4; -.
DR BioGRID-ORCS; 245930; 9 hits in 1031 CRISPR screens.
DR GenomeRNAi; 245930; -.
DR Pharos; Q30KQ4; Tdark.
DR PRO; PR:Q30KQ4; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q30KQ4; protein.
DR Bgee; ENSG00000215545; Expressed in cell and 20 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..102
FT /note="Beta-defensin 116"
FT /id="PRO_0000045344"
FT REGION 83..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 40..67
FT /evidence="ECO:0000250"
FT DISULFID 47..61
FT /evidence="ECO:0000250"
FT DISULFID 51..68
FT /evidence="ECO:0000250"
FT VARIANT 19
FT /note="Q -> L (in dbSNP:rs6119768)"
FT /id="VAR_048863"
SQ SEQUENCE 102 AA; 11544 MW; B8A488577CDA6925 CRC64;
MSVMKPCLMT IAILMILAQK TPGGLFRSHN GKSREPWNPC ELYQGMCRNA CREYEIQYLT
CPNDQKCCLK LSVKITSSKN VKEDYDSNSN LSVTNSSSYS HI
