ID   DB116_PANTR             Reviewed;         102 AA.
AC   Q30KL1;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Beta-defensin 116;
DE   AltName: Full=Defensin, beta 116;
DE   Flags: Precursor;
GN   Name=DEFB116;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ012068; AAY59799.1; -; mRNA.
DR   RefSeq; NP_001073397.1; NM_001079928.1.
DR   AlphaFoldDB; Q30KL1; -.
DR   SMR; Q30KL1; -.
DR   STRING; 9598.ENSPTRP00000054753; -.
DR   PaxDb; Q30KL1; -.
DR   Ensembl; ENSPTRT00000062199; ENSPTRP00000054753; ENSPTRG00000032541.
DR   GeneID; 746003; -.
DR   KEGG; ptr:746003; -.
DR   CTD; 245930; -.
DR   VGNC; VGNC:6089; DEFB116.
DR   eggNOG; ENOG502TF8H; Eukaryota.
DR   GeneTree; ENSGT00390000001502; -.
DR   HOGENOM; CLU_2482789_0_0_1; -.
DR   InParanoid; Q30KL1; -.
DR   OMA; NACRKYE; -.
DR   OrthoDB; 1588126at2759; -.
DR   Proteomes; UP000002277; Chromosome 20.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..102
FT                   /note="Beta-defensin 116"
FT                   /id="PRO_0000045345"
FT   REGION          83..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        40..67
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        51..68
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   102 AA;  11544 MW;  B8A488577CDA6925 CRC64;
     MSVMKPCLMT IAILMILAQK TPGGLFRSHN GKSREPWNPC ELYQGMCRNA CREYEIQYLT
     CPNDQKCCLK LSVKITSSKN VKEDYDSNSN LSVTNSSSYS HI