ID   ACTP1_TERSU             Reviewed;         207 AA.
AC   P0DN67;
DT   09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT   09-DEC-2015, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=Tereporin-Ts1 {ECO:0000305};
DE   AltName: Full=Actinoporin-like protein {ECO:0000305};
DE   Flags: Precursor; Fragment;
OS   Terebra subulata (Chocolate spotted auger) (Buccinum subulatum).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Terebridae; Terebra.
OX   NCBI_TaxID=89435;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Gorson J., Anand P., Holford M.;
RL   Unpublished observations (OCT-2015).
CC   -!- FUNCTION: Pore-forming protein that forms pores of around 1 nm and
CC       causes cardiac stimulation and hemolysis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Target cell membrane
CC       {ECO:0000250}. Note=Forms an alpha-helical membrane channel in the
CC       prey. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|Ref.1}.
CC   -!- SIMILARITY: Belongs to the actinoporin family. Conoidea subfamily.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P0DN67; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.270.20; -; 1.
DR   InterPro; IPR015926; Cytolysin/lectin.
DR   SUPFAM; SSF63724; SSF63724; 1.
PE   2: Evidence at transcript level;
KW   Cytolysis; Hemolysis; Ion transport; Membrane; Secreted; Signal;
KW   Target cell membrane; Target membrane; Toxin; Transmembrane; Transport.
FT   SIGNAL          <1..11
FT                   /evidence="ECO:0000250|UniProtKB:P0DKQ8"
FT   CHAIN           12..>207
FT                   /note="Tereporin-Ts1"
FT                   /id="PRO_0000435101"
FT   NON_TER         1
FT   NON_TER         207
SQ   SEQUENCE   207 AA;  22598 MW;  39761F7C95EA6B18 CRC64;
     VIFALVLGNA SPVQSVAITA TAVATAIGAA SQIISAGTSL ASTILSGLAA SGYRVTCAIQ
     VENWTRYPLI YATVQINRNA AVTVSPSSIL PGKREGFSVR MPNGLAEGVY GTVSWELLGI
     KRRFVLMWSA PFNFNHFSNW MGVGLTRPGI TKVPSGMTWF NKMYYDKTGR VGNLHFERGE
     FYYETNPVIY RDSKFEIEGT MTNIHNA