ID   DB119_BOVIN             Reviewed;          83 AA.
AC   Q32P86; A7LM95;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Beta-defensin 119;
DE   AltName: Full=Defensin, beta 119;
DE   Flags: Precursor;
GN   Name=DEFB119;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Cormican P., Meade K.G., Lloyd A.T., Cahalane S., Narciandi F.,
RA   O'Farrelly C.;
RT   "Novel bovine AMPs exhibit constitutive tissue-specific gene expression and
RT   significant in vitro antimicrobial efficacy against Escherichia coli,
RT   Salmonella typhimurium, Stapylococcus aureus and Listeria monocytogenes.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; EU036209; ABS86885.1; -; mRNA.
DR   EMBL; BC108216; AAI08217.1; -; mRNA.
DR   RefSeq; NP_001095131.1; NM_001101661.2.
DR   AlphaFoldDB; Q32P86; -.
DR   STRING; 9913.ENSBTAP00000004362; -.
DR   PaxDb; Q32P86; -.
DR   Ensembl; ENSBTAT00000067391; ENSBTAP00000060931; ENSBTAG00000003364.
DR   GeneID; 767957; -.
DR   KEGG; bta:767957; -.
DR   CTD; 245932; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003364; -.
DR   VGNC; VGNC:106428; DEFB119.
DR   eggNOG; ENOG502TDXM; Eukaryota.
DR   GeneTree; ENSGT00510000050451; -.
DR   HOGENOM; CLU_193927_0_0_1; -.
DR   InParanoid; Q32P86; -.
DR   OMA; HHTLRCM; -.
DR   OrthoDB; 1571101at2759; -.
DR   Reactome; R-BTA-1461957; Beta defensins.
DR   Reactome; R-BTA-1461973; Defensins.
DR   Proteomes; UP000009136; Chromosome 13.
DR   Bgee; ENSBTAG00000003364; Expressed in caput epididymis and 26 other tissues.
DR   ExpressionAtlas; Q32P86; baseline.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central.
DR   GO; GO:0061760; P:antifungal innate immune response; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         21..83
FT                   /note="Beta-defensin 119"
FT                   /id="PRO_0000285787"
FT   DISULFID        27..54
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..48
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..55
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   83 AA;  9805 MW;  43DA856ACEB163D8 CRC64;
     MKFLFLFLAI LLAMEPVVSG RRHMLRCMGD LGICRPACRQ SEEPYLYCRN YQPCCLPFYV
     RIDISGKEGK NDWSRENRWP KVS