ID   DB119_CANLF             Reviewed;          82 AA.
AC   Q30KT5;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Beta-defensin 119;
DE   AltName: Full=Defensin, beta 119;
DE   Flags: Precursor;
GN   Name=DEFB119; Synonyms=CBD119;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ011988; AAY59725.1; -; mRNA.
DR   AlphaFoldDB; Q30KT5; -.
DR   STRING; 9615.ENSCAFP00000034531; -.
DR   Ensembl; ENSCAFT00000108341; ENSCAFP00000068092; ENSCAFG00000052287.
DR   Ensembl; ENSCAFT00030015062; ENSCAFP00030013129; ENSCAFG00030008221.
DR   Ensembl; ENSCAFT00040039145; ENSCAFP00040034137; ENSCAFG00040021114.
DR   Ensembl; ENSCAFT00845031594; ENSCAFP00845024731; ENSCAFG00845017855.
DR   VEuPathDB; HostDB:ENSCAFG00845017855; -.
DR   GeneTree; ENSGT00510000050451; -.
DR   HOGENOM; CLU_193927_0_0_1; -.
DR   InParanoid; Q30KT5; -.
DR   Reactome; R-CFA-1461957; Beta defensins.
DR   Reactome; R-CFA-1461973; Defensins.
DR   Proteomes; UP000002254; Chromosome 24.
DR   Bgee; ENSCAFG00000006989; Expressed in testis and 4 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central.
DR   GO; GO:0061760; P:antifungal innate immune response; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         20..82
FT                   /note="Beta-defensin 119"
FT                   /id="PRO_0000285788"
FT   DISULFID        26..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        33..47
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..54
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   82 AA;  9726 MW;  6767C2DAE1CE2384 CRC64;
     MKFFLFFVIL LAMEPVISGK HHILRCMGNT GICRPSCRKT EQPYLYCLNY QSCCLQSYMR
     ISISGREEKD DWSQQNRWPK IS