ID   DB119_GORGO             Reviewed;          84 AA.
AC   A4H225; A4H230;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Beta-defensin 119;
DE   AltName: Full=Beta-defensin 120;
DE   AltName: Full=Defensin, beta 119;
DE   AltName: Full=Defensin, beta 120;
DE   Flags: Precursor;
GN   Name=DEFB119; Synonyms=DEFB120;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A4H225-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A4H225-2; Sequence=VSP_029870;
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AM410130; CAL68945.1; -; Genomic_DNA.
DR   EMBL; AM410135; CAL68950.1; -; Genomic_DNA.
DR   RefSeq; XP_004061991.1; XM_004061943.1. [A4H225-1]
DR   AlphaFoldDB; A4H225; -.
DR   Ensembl; ENSGGOT00000027291; ENSGGOP00000024051; ENSGGOG00000005372. [A4H225-1]
DR   GeneID; 101138717; -.
DR   KEGG; ggo:101138717; -.
DR   CTD; 245932; -.
DR   GeneTree; ENSGT00390000000279; -.
DR   HOGENOM; CLU_193927_0_0_1; -.
DR   InParanoid; A4H225; -.
DR   OMA; HHTLRCM; -.
DR   Proteomes; UP000001519; Chromosome 20.
DR   Bgee; ENSGGOG00000005372; Expressed in testis.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central.
DR   GO; GO:0061760; P:antifungal innate immune response; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Antibiotic; Antimicrobial; Defensin; Disulfide bond;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         22..84
FT                   /note="Beta-defensin 119"
FT                   /id="PRO_0000289830"
FT   DISULFID        28..55
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..49
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..56
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         21..84
FT                   /note="GKRHILRCMGNSGICRASCKKNEQPYLYCRNYQSCCLQSYMRISISGKEEDT
FT                   DWSYEKQWPRLP -> VECWMDGHCRLLCKDGEDSIIRCRNRKRCCVPSHYLTIQPVTI
FT                   HGILGWTTPQMSTTAPKTKTNITNR (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_029870"
SQ   SEQUENCE   84 AA;  9883 MW;  189763812A6FE8B1 CRC64;
     MKLLYLFLAI LLAIEEPVIS GKRHILRCMG NSGICRASCK KNEQPYLYCR NYQSCCLQSY
     MRISISGKEE DTDWSYEKQW PRLP