ID   DB119_MACMU             Reviewed;          84 AA.
AC   Q5J602; Q5J601;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Beta-defensin 119;
DE   AltName: Full=Beta-defensin 120;
DE   AltName: Full=Defensin, beta 119;
DE   AltName: Full=Defensin, beta 120;
DE   Flags: Precursor;
GN   Name=DEFB119; Synonyms=DEFB120;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=15772680; DOI=10.1038/sj.gene.6364184;
RA   Radhakrishnan Y., Hamil K.G., Yenugu S., Young S.L., French F.S.,
RA   Hall S.H.;
RT   "Identification, characterization, and evolution of a primate beta-defensin
RT   gene cluster.";
RL   Genes Immun. 6:203-210(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5J602-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5J602-2; Sequence=VSP_029874;
CC   -!- TISSUE SPECIFICITY: Abundant expression in the male reproductive tract
CC       only. Expressed abundantly in testis, while expression in epididymis
CC       decreased gradually from caput to cauda. {ECO:0000269|PubMed:15772680}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AY499406; AAS89325.1; -; mRNA.
DR   EMBL; AY499407; AAS89326.1; -; mRNA.
DR   RefSeq; NP_001028080.1; NM_001032908.1. [Q5J602-1]
DR   RefSeq; NP_001028081.1; NM_001032909.1. [Q5J602-2]
DR   RefSeq; XP_015004774.1; XM_015149288.1. [Q5J602-2]
DR   AlphaFoldDB; Q5J602; -.
DR   SMR; Q5J602; -.
DR   Ensembl; ENSMMUT00000012296; ENSMMUP00000011534; ENSMMUG00000008796. [Q5J602-1]
DR   Ensembl; ENSMMUT00000012298; ENSMMUP00000011536; ENSMMUG00000008796. [Q5J602-2]
DR   GeneID; 574286; -.
DR   GeneID; 574287; -.
DR   KEGG; mcc:574286; -.
DR   CTD; 245932; -.
DR   VEuPathDB; HostDB:ENSMMUG00000008796; -.
DR   GeneTree; ENSGT00390000000279; -.
DR   HOGENOM; CLU_193927_0_0_1; -.
DR   InParanoid; Q5J602; -.
DR   OMA; HHTLRCM; -.
DR   Proteomes; UP000006718; Chromosome 10.
DR   Bgee; ENSMMUG00000008796; Expressed in testis and 7 other tissues.
DR   ExpressionAtlas; Q5J602; baseline.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central.
DR   GO; GO:0061760; P:antifungal innate immune response; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Antibiotic; Antimicrobial; Defensin; Disulfide bond;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         22..84
FT                   /note="Beta-defensin 119"
FT                   /id="PRO_0000006988"
FT   DISULFID        28..55
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..49
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..56
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         21..84
FT                   /note="GKRHILRCMGNSGICRASCKKNEQPYLYCRNYQACCLQSYMRISISGKEENT
FT                   DWSYEKQWPRLP -> VECWMDGHCRLLCKDGEDSIIRCRNRKRCCVPSRYLTIQPVTI
FT                   HGILGWTTPRMSTTAPQPKRNIHNG (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15772680"
FT                   /id="VSP_029874"
SQ   SEQUENCE   84 AA;  9842 MW;  EDC3F6DFE21E9510 CRC64;
     MKFLFLFLAI LLATEVPVIS GKRHILRCMG NSGICRASCK KNEQPYLYCR NYQACCLQSY
     MRISISGKEE NTDWSYEKQW PRLP