DB119_PANTR
ID DB119_PANTR Reviewed; 84 AA.
AC Q30KK8; A4H224; A4H229; Q30KK7;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Beta-defensin 119;
DE AltName: Full=Beta-defensin 120;
DE AltName: Full=Defensin, beta 119;
DE AltName: Full=Defensin, beta 120;
DE Flags: Precursor;
GN Name=DEFB119; Synonyms=DEFB120;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
RA Hollox E.J., Armour J.A.L.;
RT "Evolution and sequence variation of human beta-defensin genes.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q30KK8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q30KK8-2; Sequence=VSP_029875;
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; DQ012071; AAY59802.1; -; mRNA.
DR EMBL; DQ012072; AAY59803.1; -; mRNA.
DR EMBL; AM410129; CAL68944.1; -; Genomic_DNA.
DR EMBL; AM410134; CAL68949.1; -; Genomic_DNA.
DR RefSeq; NP_001095143.1; NM_001101673.1. [Q30KK8-1]
DR RefSeq; XP_009435280.1; XM_009437005.2. [Q30KK8-2]
DR AlphaFoldDB; Q30KK8; -.
DR STRING; 9598.ENSPTRP00000022889; -.
DR PaxDb; Q30KK8; -.
DR Ensembl; ENSPTRT00000024799; ENSPTRP00000022889; ENSPTRG00000013351. [Q30KK8-1]
DR Ensembl; ENSPTRT00000086147; ENSPTRP00000071557; ENSPTRG00000013351. [Q30KK8-2]
DR GeneID; 746052; -.
DR KEGG; ptr:746052; -.
DR CTD; 245932; -.
DR eggNOG; ENOG502TDXM; Eukaryota.
DR GeneTree; ENSGT00390000000279; -.
DR HOGENOM; CLU_193927_0_0_1; -.
DR InParanoid; Q30KK8; -.
DR OMA; HHTLRCM; -.
DR Proteomes; UP000002277; Chromosome 20.
DR Bgee; ENSPTRG00000013351; Expressed in testis and 1 other tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central.
DR GO; GO:0061760; P:antifungal innate immune response; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Antibiotic; Antimicrobial; Defensin; Disulfide bond;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PEPTIDE 22..84
FT /note="Beta-defensin 119"
FT /id="PRO_0000045348"
FT DISULFID 35..49
FT /evidence="ECO:0000250"
FT DISULFID 39..56
FT /evidence="ECO:0000250"
FT VAR_SEQ 21..84
FT /note="GKRHILRRMGNSGICRASCKKNEQPYLYCRNYQSCCLQSYMRISISGKEENT
FT DWSYEKQWPRLP -> VECWMDGHCRLLCKDGEDSIIRCRNRKRCCVPSRYLTIQPVTI
FT HGILGWTTPQMSTTAPKTKTNITNR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16033865"
FT /id="VSP_029875"
SQ SEQUENCE 84 AA; 9935 MW; 098663903B674AB1 CRC64;
MKLLYLFLAI LLAIEEPVIS GKRHILRRMG NSGICRASCK KNEQPYLYCR NYQSCCLQSY
MRISISGKEE NTDWSYEKQW PRLP
