ID   DB119_PONPY             Reviewed;          84 AA.
AC   A4H226; A4H231;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Beta-defensin 119;
DE   AltName: Full=Beta-defensin 120;
DE   AltName: Full=Defensin, beta 119;
DE   AltName: Full=Defensin, beta 120;
DE   Flags: Precursor;
GN   Name=DEFB119; Synonyms=DEFB120;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A4H226-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A4H226-2; Sequence=VSP_029876;
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AM410131; CAL68946.1; -; Genomic_DNA.
DR   EMBL; AM410136; CAL68951.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4H226; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Antibiotic; Antimicrobial; Defensin; Disulfide bond;
KW   Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         22..84
FT                   /note="Beta-defensin 119"
FT                   /id="PRO_0000289833"
FT   DISULFID        28..55
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..49
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..56
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         21..84
FT                   /note="GKRYILRCMGNSGICRASCKRNEQPYLYCKNYQSCCLQSYMRISISGKEENT
FT                   DWSYEKQWPKLP -> VECWMDGHCRLLCKDGEDSIIRCRNRKRCCVPSHYLTIQPVTI
FT                   HGILGWTTPQMPTTAPKAKRNITNR (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_029876"
SQ   SEQUENCE   84 AA;  9908 MW;  0BAC70741B7AA7BF CRC64;
     MKLLYLFLAI LLVIEEPVIS GKRYILRCMG NSGICRASCK RNEQPYLYCK NYQSCCLQSY
     MRISISGKEE NTDWSYEKQW PKLP