DB121_HUMAN
ID DB121_HUMAN Reviewed; 76 AA.
AC Q5J5C9; A1L4N1;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Beta-defensin 121;
DE AltName: Full=Beta-defensin 21;
DE Short=DEFB-21;
DE AltName: Full=Defensin, beta 121;
DE Flags: Precursor;
GN Name=DEFB121; Synonyms=DEFB21;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=15772680; DOI=10.1038/sj.gene.6364184;
RA Radhakrishnan Y., Hamil K.G., Yenugu S., Young S.L., French F.S.,
RA Hall S.H.;
RT "Identification, characterization, and evolution of a primate beta-defensin
RT gene cluster.";
RL Genes Immun. 6:203-210(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC -!- INTERACTION:
CC Q5J5C9; P25942: CD40; NbExp=3; IntAct=EBI-10244198, EBI-525714;
CC Q5J5C9; Q9UHP7-3: CLEC2D; NbExp=3; IntAct=EBI-10244198, EBI-11749983;
CC Q5J5C9; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-10244198, EBI-18304435;
CC Q5J5C9; P48165: GJA8; NbExp=3; IntAct=EBI-10244198, EBI-17458373;
CC Q5J5C9; Q6UWB1: IL27RA; NbExp=3; IntAct=EBI-10244198, EBI-19045531;
CC Q5J5C9; Q6UX15-2: LAYN; NbExp=3; IntAct=EBI-10244198, EBI-19944128;
CC Q5J5C9; Q8N386: LRRC25; NbExp=3; IntAct=EBI-10244198, EBI-11304917;
CC Q5J5C9; Q96NY8: NECTIN4; NbExp=3; IntAct=EBI-10244198, EBI-4314784;
CC Q5J5C9; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-10244198, EBI-17280858;
CC Q5J5C9; Q8N205: SYNE4; NbExp=3; IntAct=EBI-10244198, EBI-7131783;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Abundant expression in the male reproductive tract
CC only. {ECO:0000269|PubMed:15772680}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AY501000; AAS87294.1; -; mRNA.
DR EMBL; AL121751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC130607; AAI30608.1; -; mRNA.
DR EMBL; BC130609; AAI30610.1; -; mRNA.
DR CCDS; CCDS33456.1; -.
DR RefSeq; NP_001011878.1; NM_001011878.2.
DR AlphaFoldDB; Q5J5C9; -.
DR SMR; Q5J5C9; -.
DR BioGRID; 128847; 32.
DR IntAct; Q5J5C9; 18.
DR STRING; 9606.ENSP00000417128; -.
DR iPTMnet; Q5J5C9; -.
DR PhosphoSitePlus; Q5J5C9; -.
DR BioMuta; DEFB121; -.
DR DMDM; 61212937; -.
DR PaxDb; Q5J5C9; -.
DR PeptideAtlas; Q5J5C9; -.
DR PRIDE; Q5J5C9; -.
DR ProteomicsDB; 62979; -.
DR Antibodypedia; 49719; 74 antibodies from 16 providers.
DR DNASU; 245934; -.
DR Ensembl; ENST00000376314.3; ENSP00000417128.1; ENSG00000204548.4.
DR GeneID; 245934; -.
DR KEGG; hsa:245934; -.
DR MANE-Select; ENST00000376314.3; ENSP00000417128.1; NM_001011878.3; NP_001011878.1.
DR UCSC; uc002wvv.3; human.
DR CTD; 245934; -.
DR DisGeNET; 245934; -.
DR GeneCards; DEFB121; -.
DR HGNC; HGNC:18101; DEFB121.
DR HPA; ENSG00000204548; Tissue enriched (epididymis).
DR MIM; 616075; gene.
DR neXtProt; NX_Q5J5C9; -.
DR OpenTargets; ENSG00000204548; -.
DR PharmGKB; PA38497; -.
DR VEuPathDB; HostDB:ENSG00000204548; -.
DR eggNOG; ENOG502TDXP; Eukaryota.
DR GeneTree; ENSGT00730000111628; -.
DR HOGENOM; CLU_181906_2_1_1; -.
DR InParanoid; Q5J5C9; -.
DR OMA; TPAMKCW; -.
DR OrthoDB; 1627249at2759; -.
DR PhylomeDB; Q5J5C9; -.
DR PathwayCommons; Q5J5C9; -.
DR Reactome; R-HSA-1461957; Beta defensins.
DR Reactome; R-HSA-1461973; Defensins.
DR SignaLink; Q5J5C9; -.
DR BioGRID-ORCS; 245934; 19 hits in 1034 CRISPR screens.
DR GenomeRNAi; 245934; -.
DR Pharos; Q5J5C9; Tdark.
DR PRO; PR:Q5J5C9; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q5J5C9; protein.
DR Bgee; ENSG00000204548; Expressed in right testis and 11 other tissues.
DR ExpressionAtlas; Q5J5C9; baseline and differential.
DR Genevisible; Q5J5C9; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..76
FT /note="Beta-defensin 121"
FT /id="PRO_0000006991"
FT DISULFID 23..50
FT /evidence="ECO:0000250"
FT DISULFID 30..44
FT /evidence="ECO:0000250"
FT DISULFID 34..51
FT /evidence="ECO:0000250"
SQ SEQUENCE 76 AA; 8456 MW; 1B80ECF2491B2E18 CRC64;
MKLLLLLLTV TLLLAQVTPV MKCWGKSGRC RTTCKESEVY YILCKTEAKC CVDPKYVPVK
PKLTDTNTSL ESTSAV
