ID   DB121_PANTR             Reviewed;          76 AA.
AC   Q30KK6;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Beta-defensin 121;
DE   AltName: Full=Defensin, beta 121;
DE   Flags: Precursor;
GN   Name=DEFB121;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012073; AAY59804.1; -; mRNA.
DR   RefSeq; NP_001123239.1; NM_001129767.1.
DR   AlphaFoldDB; Q30KK6; -.
DR   SMR; Q30KK6; -.
DR   STRING; 9598.ENSPTRP00000052303; -.
DR   PaxDb; Q30KK6; -.
DR   Ensembl; ENSPTRT00000059187; ENSPTRP00000052303; ENSPTRG00000030595.
DR   GeneID; 746082; -.
DR   KEGG; ptr:746082; -.
DR   CTD; 245934; -.
DR   VGNC; VGNC:6090; DEFB121.
DR   eggNOG; ENOG502TDXP; Eukaryota.
DR   GeneTree; ENSGT00730000111628; -.
DR   HOGENOM; CLU_181906_2_1_1; -.
DR   InParanoid; Q30KK6; -.
DR   OMA; TPAMKCW; -.
DR   OrthoDB; 1627249at2759; -.
DR   Proteomes; UP000002277; Chromosome 20.
DR   Bgee; ENSPTRG00000030595; Expressed in testis.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..76
FT                   /note="Beta-defensin 121"
FT                   /id="PRO_0000045350"
FT   DISULFID        23..50
FT                   /evidence="ECO:0000250"
FT   DISULFID        30..44
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..51
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   76 AA;  8511 MW;  1B80EB6C491B2E18 CRC64;
     MKLLLLLLTV TLLLAQVTPV MKCWGKSGRC RTTCKESEVY YILCKTEAKC CVDPKYVPVK
     PKLTDRNTSL ESTSAV