ID   DB122_MACMU             Reviewed;          69 AA.
AC   Q5J5Z9;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Beta-defensin 122;
DE   AltName: Full=Defensin, beta 122;
DE   Flags: Precursor;
GN   Name=DEFB122;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Epididymis;
RA   Yashwanth R., Hamil K.G., Yenugu S., French F.S., Hall S.H.;
RT   "Differential expression of a primate beta defensin gene cluster specific
RT   to male reproductive tract.";
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AY499409; AAS89328.1; -; mRNA.
DR   RefSeq; NP_001029368.1; NM_001034196.1.
DR   AlphaFoldDB; Q5J5Z9; -.
DR   SMR; Q5J5Z9; -.
DR   STRING; 9544.ENSMMUP00000023075; -.
DR   GeneID; 619506; -.
DR   KEGG; mcc:619506; -.
DR   CTD; 245935; -.
DR   eggNOG; ENOG502TD2F; Eukaryota.
DR   HOGENOM; CLU_181906_2_0_1; -.
DR   InParanoid; Q5J5Z9; -.
DR   OMA; KFYVFCL; -.
DR   OrthoDB; 1613424at2759; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..69
FT                   /note="Beta-defensin 122"
FT                   /id="PRO_0000006993"
FT   DISULFID        26..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        33..47
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..54
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   69 AA;  7953 MW;  6C13A08A2C343768 CRC64;
     MKPFLVTLAV LLLFFQVTAV GSIEKCWNFR GSCRDECLKN EKVYVFCMSG KLCCLKPKDQ
     PHLPQRTKN