ID   DB123_GORGO             Reviewed;          67 AA.
AC   A4H235;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Beta-defensin 123;
DE   AltName: Full=Defensin, beta 123;
DE   Flags: Precursor;
GN   Name=DEFB123;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM410140; CAL68955.1; -; Genomic_DNA.
DR   RefSeq; XP_004061994.1; XM_004061946.1.
DR   AlphaFoldDB; A4H235; -.
DR   SMR; A4H235; -.
DR   STRING; 9593.ENSGGOP00000000869; -.
DR   PRIDE; A4H235; -.
DR   Ensembl; ENSGGOT00000000888; ENSGGOP00000000869; ENSGGOG00000000884.
DR   GeneID; 101140157; -.
DR   KEGG; ggo:101140157; -.
DR   CTD; 245936; -.
DR   eggNOG; ENOG502TIGY; Eukaryota.
DR   GeneTree; ENSGT00940000162385; -.
DR   HOGENOM; CLU_181906_2_0_1; -.
DR   InParanoid; A4H235; -.
DR   OMA; VYVYCTN; -.
DR   OrthoDB; 1606248at2759; -.
DR   Proteomes; UP000001519; Chromosome 20.
DR   Bgee; ENSGGOG00000000884; Expressed in testis and 1 other tissue.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         21..67
FT                   /note="Beta-defensin 123"
FT                   /id="PRO_0000289838"
FT   DISULFID        25..52
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..46
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..53
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   67 AA;  8105 MW;  94EBFE98C9086D72 CRC64;
     MKLLLLTLTV LLLLSQLTPG GTQRCWNLYG KCRYRCSKKE RVYVYCINNK MCCVKPKYQP
     KERWWPF