ID   DB123_MACMU             Reviewed;          67 AA.
AC   Q5J5D0;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Beta-defensin 123;
DE   AltName: Full=Defensin, beta 123;
DE   Flags: Precursor;
GN   Name=DEFB123;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=15772680; DOI=10.1038/sj.gene.6364184;
RA   Radhakrishnan Y., Hamil K.G., Yenugu S., Young S.L., French F.S.,
RA   Hall S.H.;
RT   "Identification, characterization, and evolution of a primate beta-defensin
RT   gene cluster.";
RL   Genes Immun. 6:203-210(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Abundant expression in the male reproductive tract
CC       only. Expressed abundantly in testis, while expression in epididymis
CC       decreased gradually from caput to cauda. {ECO:0000269|PubMed:15772680}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AY500998; AAS87293.1; -; mRNA.
DR   RefSeq; NP_001029367.1; NM_001034195.1.
DR   AlphaFoldDB; Q5J5D0; -.
DR   SMR; Q5J5D0; -.
DR   STRING; 9544.ENSMMUP00000006778; -.
DR   PRIDE; Q5J5D0; -.
DR   Ensembl; ENSMMUT00000078866; ENSMMUP00000058082; ENSMMUG00000046141.
DR   GeneID; 619504; -.
DR   KEGG; mcc:619504; -.
DR   CTD; 245936; -.
DR   VEuPathDB; HostDB:ENSMMUG00000046141; -.
DR   eggNOG; ENOG502TIGY; Eukaryota.
DR   GeneTree; ENSGT00940000162385; -.
DR   HOGENOM; CLU_181906_2_0_1; -.
DR   InParanoid; Q5J5D0; -.
DR   OrthoDB; 1606248at2759; -.
DR   Proteomes; UP000006718; Chromosome 10.
DR   Bgee; ENSMMUG00000046141; Expressed in testis and 3 other tissues.
DR   ExpressionAtlas; Q5J5D0; baseline.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         21..67
FT                   /note="Beta-defensin 123"
FT                   /id="PRO_0000006995"
FT   DISULFID        25..52
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..46
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..53
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   67 AA;  8051 MW;  94F0E429688EDD72 CRC64;
     MKLLLLTLTV LLLLSQLTPG GTQRCWNLYG KCRHRCSKKE RVYVYCLNNK MCCVKPKYQP
     KEKWWPF