ID   DB123_PANTR             Reviewed;          67 AA.
AC   Q30KK5; A4H234;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Beta-defensin 123;
DE   AltName: Full=Defensin, beta 123;
DE   Flags: Precursor;
GN   Name=DEFB123;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012075; AAY59805.1; -; mRNA.
DR   EMBL; AM410139; CAL68954.1; -; Genomic_DNA.
DR   RefSeq; NP_001123240.1; NM_001129768.1.
DR   AlphaFoldDB; Q30KK5; -.
DR   SMR; Q30KK5; -.
DR   STRING; 9598.ENSPTRP00000022892; -.
DR   PaxDb; Q30KK5; -.
DR   Ensembl; ENSPTRT00000024802; ENSPTRP00000022892; ENSPTRG00000013352.
DR   GeneID; 742057; -.
DR   KEGG; ptr:742057; -.
DR   CTD; 245936; -.
DR   VGNC; VGNC:6091; DEFB123.
DR   eggNOG; ENOG502TIGY; Eukaryota.
DR   GeneTree; ENSGT00940000162385; -.
DR   HOGENOM; CLU_181906_2_0_1; -.
DR   InParanoid; Q30KK5; -.
DR   OMA; VYVYCTN; -.
DR   OrthoDB; 1606248at2759; -.
DR   TreeFam; TF336381; -.
DR   Proteomes; UP000002277; Chromosome 20.
DR   Bgee; ENSPTRG00000013352; Expressed in testis.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         21..67
FT                   /note="Beta-defensin 123"
FT                   /id="PRO_0000045351"
FT   DISULFID        25..52
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..46
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..53
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   67 AA;  8105 MW;  94EBFE98C9086D72 CRC64;
     MKLLLLTLTV LLLLSQLTPG GTQRCWNLYG KCRYRCSKKE RVYVYCINNK MCCVKPKYQP
     KERWWPF