ID   DB124_PANTR             Reviewed;          71 AA.
AC   Q30KK4;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Beta-defensin 124;
DE   AltName: Full=Defensin, beta 124;
DE   Flags: Precursor;
GN   Name=DEFB124;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012076; AAY59806.1; -; mRNA.
DR   RefSeq; NP_001123241.1; NM_001129769.1.
DR   RefSeq; XP_016793116.1; XM_016937627.1.
DR   RefSeq; XP_016793117.1; XM_016937628.1.
DR   RefSeq; XP_016793118.1; XM_016937629.1.
DR   RefSeq; XP_016802566.1; XM_016947077.1.
DR   RefSeq; XP_016802567.1; XM_016947078.1.
DR   RefSeq; XP_016802568.1; XM_016947079.1.
DR   AlphaFoldDB; Q30KK4; -.
DR   SMR; Q30KK4; -.
DR   STRING; 9598.ENSPTRP00000022893; -.
DR   PaxDb; Q30KK4; -.
DR   Ensembl; ENSPTRT00000024803; ENSPTRP00000022893; ENSPTRG00000013353.
DR   GeneID; 742102; -.
DR   KEGG; ptr:742102; -.
DR   CTD; 245937; -.
DR   VGNC; VGNC:6092; DEFB124.
DR   eggNOG; ENOG502TF15; Eukaryota.
DR   GeneTree; ENSGT00530000064308; -.
DR   HOGENOM; CLU_181906_4_0_1; -.
DR   InParanoid; Q30KK4; -.
DR   OMA; FMHLCPD; -.
DR   OrthoDB; 1608867at2759; -.
DR   Proteomes; UP000002277; Chromosome 20.
DR   Bgee; ENSPTRG00000013353; Expressed in testis and 5 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0071224; P:cellular response to peptidoglycan; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   GO; GO:0071651; P:positive regulation of chemokine (C-C motif) ligand 5 production; IBA:GO_Central.
DR   GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IBA:GO_Central.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..71
FT                   /note="Beta-defensin 124"
FT                   /id="PRO_0000045353"
FT   DISULFID        27..54
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..48
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..55
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   71 AA;  8087 MW;  1BF1F37F431F3F99 CRC64;
     MTQLLLFLVA LLVLGHVPSG RSEFKRCWKG QGACRTYCTR QETYMHLCPD ASLCCLSYAL
     KPPPVPKHEY E