ID   DB125_GORGO             Reviewed;         157 AA.
AC   A4H238;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Beta-defensin 125;
DE   AltName: Full=Defensin, beta 125;
DE   Flags: Precursor;
GN   Name=DEFB125;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AM410143; CAL68982.1; -; Genomic_DNA.
DR   RefSeq; XP_004061672.1; XM_004061624.2.
DR   AlphaFoldDB; A4H238; -.
DR   STRING; 9593.ENSGGOP00000026067; -.
DR   Ensembl; ENSGGOT00000032192; ENSGGOP00000026067; ENSGGOG00000026876.
DR   eggNOG; ENOG502RU2M; Eukaryota.
DR   GeneTree; ENSGT00390000000604; -.
DR   HOGENOM; CLU_152039_0_0_1; -.
DR   InParanoid; A4H238; -.
DR   OMA; CFHVERY; -.
DR   OrthoDB; 1461402at2759; -.
DR   Proteomes; UP000001519; Chromosome 20.
DR   Bgee; ENSGGOG00000026876; Expressed in adult mammalian kidney.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..157
FT                   /note="Beta-defensin 125"
FT                   /id="PRO_0000289840"
FT   REGION          109..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        27..55
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..49
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..56
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   157 AA;  17688 MW;  ABD13C1A761CD7C8 CRC64;
     MNILMLTFII CGLLTQVTKG SFEPQKCWKN NIGHCRRRCL DTERCILLCR NKLSCCIYII
     ISHEYTQRPA FPMIHLEDIT FDYSDVDSFT GSPVSMLNDL ITFDTTKFGE TMTPETNTPE
     TTVPPSETTT PETTMPPSET ATSETMPPPS QTALTHN