DB125_HUMAN
ID DB125_HUMAN Reviewed; 156 AA.
AC Q8N687; A1A502; Q7Z7B9;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Beta-defensin 125;
DE AltName: Full=Beta-defensin 25;
DE Short=DEFB-25;
DE AltName: Full=Defensin, beta 125;
DE Flags: Precursor;
GN Name=DEFB125; Synonyms=DEFB25;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=12620395; DOI=10.1016/s0888-7543(02)00034-4;
RA Rodriguez-Jimenez F.-J., Krause A., Schulz S., Forssmann W.-G.,
RA Conejo-Garcia J.-R., Schreeb R., Motzkus D.;
RT "Distribution of new human beta-defensin genes clustered on chromosome 20
RT in functionally different segments of epididymis.";
RL Genomics 81:175-183(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 5-156, AND IDENTIFICATION.
RC TISSUE=B-cell, Fetal lung, and Testis;
RX PubMed=11854508; DOI=10.1073/pnas.042692699;
RA Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P.,
RA Welsh M.J., Casavant T.L., McCray P.B. Jr.;
RT "Discovery of five conserved beta-defensin gene clusters using a
RT computational search strategy.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AF525927; AAP47220.1; -; mRNA.
DR EMBL; AL360078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471133; EAX10689.1; -; Genomic_DNA.
DR EMBL; BC128195; AAI28196.1; -; mRNA.
DR EMBL; BC128196; AAI28197.1; -; mRNA.
DR EMBL; AY122477; AAM93918.1; -; mRNA.
DR CCDS; CCDS12989.2; -.
DR RefSeq; NP_697020.2; NM_153325.3.
DR AlphaFoldDB; Q8N687; -.
DR BioGRID; 128851; 46.
DR STRING; 9606.ENSP00000371847; -.
DR iPTMnet; Q8N687; -.
DR PhosphoSitePlus; Q8N687; -.
DR BioMuta; DEFB125; -.
DR DMDM; 152112501; -.
DR PaxDb; Q8N687; -.
DR PeptideAtlas; Q8N687; -.
DR PRIDE; Q8N687; -.
DR Antibodypedia; 51066; 12 antibodies from 7 providers.
DR DNASU; 245938; -.
DR Ensembl; ENST00000382410.3; ENSP00000371847.2; ENSG00000178591.7.
DR GeneID; 245938; -.
DR KEGG; hsa:245938; -.
DR MANE-Select; ENST00000382410.3; ENSP00000371847.2; NM_153325.4; NP_697020.2.
DR UCSC; uc002wcw.4; human.
DR CTD; 245938; -.
DR GeneCards; DEFB125; -.
DR HGNC; HGNC:18105; DEFB125.
DR HPA; ENSG00000178591; Group enriched (epididymis, seminal vesicle).
DR neXtProt; NX_Q8N687; -.
DR PharmGKB; PA38501; -.
DR VEuPathDB; HostDB:ENSG00000178591; -.
DR eggNOG; ENOG502RU2M; Eukaryota.
DR GeneTree; ENSGT00390000000604; -.
DR HOGENOM; CLU_152039_0_0_1; -.
DR InParanoid; Q8N687; -.
DR OMA; CFHVERY; -.
DR OrthoDB; 1461402at2759; -.
DR PhylomeDB; Q8N687; -.
DR PathwayCommons; Q8N687; -.
DR Reactome; R-HSA-1461957; Beta defensins.
DR Reactome; R-HSA-1461973; Defensins.
DR BioGRID-ORCS; 245938; 40 hits in 1058 CRISPR screens.
DR ChiTaRS; DEFB125; human.
DR GenomeRNAi; 245938; -.
DR Pharos; Q8N687; Tdark.
DR PRO; PR:Q8N687; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q8N687; protein.
DR Bgee; ENSG00000178591; Expressed in cauda epididymis and 3 other tissues.
DR Genevisible; Q8N687; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Defensin;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PEPTIDE 21..67
FT /note="Beta-defensin 125"
FT /id="PRO_0000006996"
FT PROPEP 68..156
FT /evidence="ECO:0000255"
FT /id="PRO_0000006997"
FT REGION 108..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 27..55
FT /evidence="ECO:0000250"
FT DISULFID 35..49
FT /evidence="ECO:0000250"
FT DISULFID 39..56
FT /evidence="ECO:0000250"
FT VARIANT 62
FT /note="H -> Y (in dbSNP:rs41276376)"
FT /id="VAR_061134"
SQ SEQUENCE 156 AA; 17537 MW; 4B72FD99B1F00FCD CRC64;
MNILMLTFII CGLLTRVTKG SFEPQKCWKN NVGHCRRRCL DTERYILLCR NKLSCCISII
SHEYTRRPAF PVIHLEDITL DYSDVDSFTG SPVSMLNDLI TFDTTKFGET MTPETNTPET
TMPPSEATTP ETTMPPSETA TSETMPPPSQ TALTHN
