ID   DB127_PANTR             Reviewed;          99 AA.
AC   Q30KK1;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Beta-defensin 127;
DE   AltName: Full=Defensin, beta 127;
DE   Flags: Precursor;
GN   Name=DEFB127;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012079; AAY59809.1; -; mRNA.
DR   RefSeq; NP_001123244.1; NM_001129772.1.
DR   AlphaFoldDB; Q30KK1; -.
DR   SMR; Q30KK1; -.
DR   STRING; 9598.ENSPTRP00000022491; -.
DR   PaxDb; Q30KK1; -.
DR   Ensembl; ENSPTRT00000024382; ENSPTRP00000022491; ENSPTRG00000013136.
DR   GeneID; 745453; -.
DR   KEGG; ptr:745453; -.
DR   CTD; 140850; -.
DR   VGNC; VGNC:13844; DEFB127.
DR   eggNOG; ENOG502TFAJ; Eukaryota.
DR   GeneTree; ENSGT00530000064502; -.
DR   HOGENOM; CLU_181906_1_0_1; -.
DR   InParanoid; Q30KK1; -.
DR   OMA; QLKKCWG; -.
DR   OrthoDB; 1495393at2759; -.
DR   Proteomes; UP000002277; Chromosome 20.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IEA:Ensembl.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Defensin;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         21..63
FT                   /note="Beta-defensin 127"
FT                   /id="PRO_0000045354"
FT   PROPEP          66..99
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000045355"
FT   DISULFID        24..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        33..47
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..54
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   99 AA;  11313 MW;  C9CBDB27CAD879B3 CRC64;
     MGLFMIIAIL LFQKPTVTEQ LKKCWNNYVQ GHCRKICRVN EVPEALCENG RYCCLNIKEL
     EACKKITKPS HPKPATLALT LQDYVTIIEN FPSLKTQST