DB128_HUMAN
ID DB128_HUMAN Reviewed; 93 AA.
AC Q7Z7B8; B2RU29;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Beta-defensin 128;
DE AltName: Full=Beta-defensin 28;
DE Short=DEFB-28;
DE AltName: Full=Defensin, beta 128;
DE Flags: Precursor;
GN Name=DEFB128; Synonyms=DEFB28;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=12620395; DOI=10.1016/s0888-7543(02)00034-4;
RA Rodriguez-Jimenez F.-J., Krause A., Schulz S., Forssmann W.-G.,
RA Conejo-Garcia J.-R., Schreeb R., Motzkus D.;
RT "Distribution of new human beta-defensin genes clustered on chromosome 20
RT in functionally different segments of epididymis.";
RL Genomics 81:175-183(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-27.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC -!- INTERACTION:
CC Q7Z7B8; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-18310688, EBI-18304435;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF525930; AAP47223.1; -; mRNA.
DR EMBL; AL360078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC140936; AAI40937.1; -; mRNA.
DR CCDS; CCDS33430.1; -.
DR RefSeq; NP_001032821.1; NM_001037732.2.
DR AlphaFoldDB; Q7Z7B8; -.
DR SMR; Q7Z7B8; -.
DR BioGRID; 128852; 1.
DR IntAct; Q7Z7B8; 1.
DR STRING; 9606.ENSP00000335382; -.
DR BioMuta; DEFB128; -.
DR DMDM; 61212983; -.
DR PaxDb; Q7Z7B8; -.
DR PeptideAtlas; Q7Z7B8; -.
DR PRIDE; Q7Z7B8; -.
DR DNASU; 245939; -.
DR Ensembl; ENST00000334391.5; ENSP00000335382.4; ENSG00000185982.7.
DR GeneID; 245939; -.
DR KEGG; hsa:245939; -.
DR MANE-Select; ENST00000334391.5; ENSP00000335382.4; NM_001037732.3; NP_001032821.1.
DR UCSC; uc002wcz.2; human.
DR CTD; 245939; -.
DR DisGeNET; 245939; -.
DR GeneCards; DEFB128; -.
DR HGNC; HGNC:18106; DEFB128.
DR HPA; ENSG00000185982; Tissue enriched (epididymis).
DR neXtProt; NX_Q7Z7B8; -.
DR OpenTargets; ENSG00000185982; -.
DR PharmGKB; PA38502; -.
DR VEuPathDB; HostDB:ENSG00000185982; -.
DR eggNOG; ENOG502TM18; Eukaryota.
DR GeneTree; ENSGT00530000064329; -.
DR HOGENOM; CLU_2399087_0_0_1; -.
DR InParanoid; Q7Z7B8; -.
DR OMA; ISEMGCL; -.
DR OrthoDB; 1568261at2759; -.
DR PhylomeDB; Q7Z7B8; -.
DR PathwayCommons; Q7Z7B8; -.
DR Reactome; R-HSA-1461957; Beta defensins.
DR Reactome; R-HSA-1461973; Defensins.
DR SignaLink; Q7Z7B8; -.
DR BioGRID-ORCS; 245939; 46 hits in 1029 CRISPR screens.
DR GenomeRNAi; 245939; -.
DR Pharos; Q7Z7B8; Tbio.
DR PRO; PR:Q7Z7B8; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q7Z7B8; protein.
DR Bgee; ENSG00000185982; Expressed in granulocyte and 15 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..93
FT /note="Beta-defensin 128"
FT /id="PRO_0000007004"
FT DISULFID 24..52
FT /evidence="ECO:0000250"
FT DISULFID 32..46
FT /evidence="ECO:0000250"
FT DISULFID 36..53
FT /evidence="ECO:0000250"
FT VARIANT 27
FT /note="K -> N (in dbSNP:rs4813043)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_048866"
SQ SEQUENCE 93 AA; 10650 MW; 8A0C1C72A876362D CRC64;
MKLFLVLIIL LFEVLTDGAR LKKCFNKVTG YCRKKCKVGE RYEIGCLSGK LCCANDEEEK
KHVSFKKPHQ HSGEKLSVLQ DYIILPTITI FTV
