ID   DB128_PONPY             Reviewed;          93 AA.
AC   A4H253;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Beta-defensin 128;
DE   AltName: Full=Defensin, beta 128;
DE   Flags: Precursor;
GN   Name=DEFB128;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AM410158; CAL68968.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4H253; -.
DR   SMR; A4H253; -.
DR   PRIDE; A4H253; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..93
FT                   /note="Beta-defensin 128"
FT                   /id="PRO_0000289853"
FT   DISULFID        24..52
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..46
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..53
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   93 AA;  10728 MW;  61863925D8732577 CRC64;
     MKLFLVLIIL LFEVLTDGAR LKKCFNNVTG YCRKKCKVGE RYEIGCLSGK LCCINYEEEK
     EHVSFKKPHQ HSGEKLSVQQ DYIILPTVTI FTV