ID   DB129_HYLLA             Reviewed;         173 AA.
AC   A4H259;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Beta-defensin 129;
DE   AltName: Full=Defensin, beta 129;
DE   Flags: Precursor;
GN   Name=DEFB129;
OS   Hylobates lar (Common gibbon) (White-handed gibbon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Hylobates.
OX   NCBI_TaxID=9580;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AM410164; CAL68974.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4H259; -.
DR   SMR; A4H259; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..173
FT                   /note="Beta-defensin 129"
FT                   /id="PRO_0000289855"
FT   REGION          144..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..173
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        27..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..48
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..54
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   173 AA;  19114 MW;  F6B520A2F4222ECF CRC64;
     MKLLFPIFAS LMLQYKVNTE FIGLRRCLMG FGRCRDHCNV DEKEIQKCKM KKCCVGPKVV
     KLIKNYLQYG TPNVLNEDVQ EMLKSAKNSS AVIQRKHILS VLPQIKSTSF FANTNFVIIP
     NATPMNSAII STVTPGQITY TAASTKSNIK ESRDSATASP PPAPPPPNTL PTP