ID   DB129_MACFA             Reviewed;         183 AA.
AC   A4H260;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Beta-defensin 129;
DE   AltName: Full=Defensin, beta 129;
DE   Flags: Precursor;
GN   Name=DEFB129;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AM410165; CAL68975.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4H260; -.
DR   SMR; A4H260; -.
DR   STRING; 9541.XP_005568664.1; -.
DR   eggNOG; ENOG502TDUT; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..183
FT                   /note="Beta-defensin 129"
FT                   /id="PRO_0000289856"
FT   REGION          142..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..156
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..172
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        27..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..48
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..54
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   183 AA;  20098 MW;  96CA049D6ADD00B1 CRC64;
     MKLLFPIFAS LMLQYQVNTE FIGLRSCLMG FGRCRDHCNV DEKEIQKCKM KKCCVGPKVV
     KLIKNYLQYG TPNVLNEDVQ EMLKPAENSS AVIQRKHILS ILPQIKSINF FANTNLVIIP
     NATPVNSATV STMTSGQITY TATSAKSNTK ESGDSATASP PPAPPPPNIL PTPSLELEEA
     EEQ