ID   DB129_PANTR             Reviewed;         183 AA.
AC   Q30KK0; A4H256;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Beta-defensin 129;
DE   AltName: Full=Defensin, beta 129;
DE   Flags: Precursor;
GN   Name=DEFB129;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012080; AAY59810.1; -; mRNA.
DR   EMBL; AM410161; CAL68971.1; -; Genomic_DNA.
DR   RefSeq; NP_001073396.1; NM_001079927.1.
DR   AlphaFoldDB; Q30KK0; -.
DR   STRING; 9598.ENSPTRP00000022492; -.
DR   PaxDb; Q30KK0; -.
DR   Ensembl; ENSPTRT00000024383; ENSPTRP00000022492; ENSPTRG00000013137.
DR   GeneID; 745478; -.
DR   KEGG; ptr:745478; -.
DR   CTD; 140881; -.
DR   VGNC; VGNC:6094; DEFB129.
DR   eggNOG; ENOG502TDUT; Eukaryota.
DR   GeneTree; ENSGT00390000008616; -.
DR   HOGENOM; CLU_1618467_0_0_1; -.
DR   InParanoid; Q30KK0; -.
DR   OMA; VNTEYFG; -.
DR   OrthoDB; 1462517at2759; -.
DR   Proteomes; UP000002277; Chromosome 20.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..183
FT                   /note="Beta-defensin 129"
FT                   /id="PRO_0000045368"
FT   REGION          141..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..156
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..172
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        27..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..48
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..54
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   183 AA;  20299 MW;  A531A68C39F6EFF9 CRC64;
     MKLLFPIFAS LMLQYQVNTE FIGLRRCLMG LGRCRDHCNV DEKEIQKCKM KKCCVGPKVV
     KLIKNYLQYG TPNVLNEDVQ EMLKPAKNSS AVIQRKHILS VLPQIKSTSF FANTNFVIIP
     NATPMNSATI STMTPGQITY TATSTKSNTK ESRDSATASP PPAPPPPNIL PTPSLELEEA
     EEQ