ID   DB129_PONPY             Reviewed;         183 AA.
AC   A4H258;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Beta-defensin 129;
DE   AltName: Full=Defensin, beta 129;
DE   Flags: Precursor;
GN   Name=DEFB129;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM410163; CAL68973.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4H258; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..183
FT                   /note="Beta-defensin 129"
FT                   /id="PRO_0000289857"
FT   REGION          141..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..156
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..172
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        27..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..48
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..54
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   183 AA;  20330 MW;  20E6DECFE21A801B CRC64;
     MKLLFPVFAS LMLQYQVNTE FIGLRRCLMG FGRCRDHCNV DEKEIQKCKM KKCCVGPKVV
     KLIKNYLQYG IPNVLNEDVQ EMLKPAKNSS AVIQRKHILS VLPQIKSTSF FANTNFVIIP
     NATPMNSATI STMTPGQITY TATSTKSNTK ESRDSATASP PPAPPPPNIL PTPSLELEKA
     EEQ