ID   DB130_PANTR             Reviewed;          79 AA.
AC   Q30KJ9;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Beta-defensin 130 {ECO:0000250|UniProtKB:P0DP74};
DE   AltName: Full=Defensin, beta 130 {ECO:0000250|UniProtKB:P0DP74};
DE   Flags: Precursor;
GN   Name=DEFB130 {ECO:0000250|UniProtKB:P0DP74};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Antimicrobial host-defense peptide.
CC       {ECO:0000250|UniProtKB:P0DP74}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012081; AAY59811.1; -; mRNA.
DR   RefSeq; NP_001123256.1; NM_001129784.1.
DR   AlphaFoldDB; Q30KJ9; -.
DR   SMR; Q30KJ9; -.
DR   STRING; 9598.ENSPTRP00000054328; -.
DR   PaxDb; Q30KJ9; -.
DR   Ensembl; ENSPTRT00000061786; ENSPTRP00000054328; ENSPTRG00000032474.
DR   GeneID; 748166; -.
DR   KEGG; ptr:748166; -.
DR   CTD; 748166; -.
DR   eggNOG; ENOG502TEXC; Eukaryota.
DR   GeneTree; ENSGT00940000160995; -.
DR   HOGENOM; CLU_191088_0_0_1; -.
DR   InParanoid; Q30KJ9; -.
DR   OMA; DDTIGVC; -.
DR   OrthoDB; 1548768at2759; -.
DR   Proteomes; UP000002277; Chromosome 11.
DR   Bgee; ENSPTRG00000032474; Expressed in bone marrow and 16 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..79
FT                   /note="Beta-defensin 130"
FT                   /id="PRO_0000045370"
FT   DISULFID        38..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..60
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   79 AA;  8736 MW;  65DF21FA1C40D507 CRC64;
     MKLHSLISVL LLFVTLIPKG KTGVIPGQKQ CIALKGVCRD KLCSTLDDTI GICNEGKKCC
     RRWWILEPYP TPVPKGKSP