DB132_HUMAN
ID DB132_HUMAN Reviewed; 95 AA.
AC Q7Z7B7; B2RP72; Q4QY40;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Beta-defensin 132;
DE AltName: Full=Beta-defensin 32;
DE Short=BD-32;
DE Short=DEFB-32;
DE AltName: Full=Defensin HEL-75;
DE AltName: Full=Defensin, beta 132;
DE Flags: Precursor;
GN Name=DEFB132; Synonyms=DEFB32; ORFNames=UNQ827/PRO1754;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=12620395; DOI=10.1016/s0888-7543(02)00034-4;
RA Rodriguez-Jimenez F.-J., Krause A., Schulz S., Forssmann W.-G.,
RA Conejo-Garcia J.-R., Schreeb R., Motzkus D.;
RT "Distribution of new human beta-defensin genes clustered on chromosome 20
RT in functionally different segments of epididymis.";
RL Genomics 81:175-183(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Patil A., Zhang G.;
RT "Genome-wide analysis of rat beta-defensins: evidence for the existence of
RT four syntenic defensin gene clusters in mammals.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Epididymis;
RX PubMed=18390568; DOI=10.1093/dnares/dsn005;
RA Li J.Y., Wang H.Y., Liu J., Liu Q., Zhang J.S., Wan F.C., Liu F.J.,
RA Jin S.H., Zhang Y.L.;
RT "Transcriptome analysis of a cDNA library from adult human epididymis.";
RL DNA Res. 15:115-122(2008).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC -!- INTERACTION:
CC Q7Z7B7; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-17250048, EBI-12142257;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC -!- CAUTION: Was termed (Ref.2) DEFB133. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF525932; AAP47225.1; -; mRNA.
DR EMBL; AY621329; AAT51868.1; -; mRNA.
DR EMBL; AY358708; AAQ89071.1; -; mRNA.
DR EMBL; EF426755; ABR09864.1; -; mRNA.
DR EMBL; AL034548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137292; AAI37293.1; -; mRNA.
DR EMBL; BC137293; AAI37294.1; -; mRNA.
DR CCDS; CCDS12993.1; -.
DR RefSeq; NP_997352.1; NM_207469.2.
DR AlphaFoldDB; Q7Z7B7; -.
DR BioGRID; 134777; 1.
DR IntAct; Q7Z7B7; 1.
DR STRING; 9606.ENSP00000371813; -.
DR BioMuta; DEFB132; -.
DR DMDM; 61212742; -.
DR MassIVE; Q7Z7B7; -.
DR PaxDb; Q7Z7B7; -.
DR PeptideAtlas; Q7Z7B7; -.
DR PRIDE; Q7Z7B7; -.
DR ProteomicsDB; 69512; -.
DR Antibodypedia; 51080; 88 antibodies from 16 providers.
DR DNASU; 400830; -.
DR Ensembl; ENST00000382376.4; ENSP00000371813.3; ENSG00000186458.5.
DR GeneID; 400830; -.
DR KEGG; hsa:400830; -.
DR MANE-Select; ENST00000382376.4; ENSP00000371813.3; NM_207469.3; NP_997352.1.
DR UCSC; uc002wdb.4; human.
DR CTD; 400830; -.
DR GeneCards; DEFB132; -.
DR HGNC; HGNC:33806; DEFB132.
DR HPA; ENSG00000186458; Tissue enriched (epididymis).
DR neXtProt; NX_Q7Z7B7; -.
DR OpenTargets; ENSG00000186458; -.
DR PharmGKB; PA162383557; -.
DR VEuPathDB; HostDB:ENSG00000186458; -.
DR eggNOG; ENOG502TE15; Eukaryota.
DR GeneTree; ENSGT00940000165094; -.
DR HOGENOM; CLU_181906_0_0_1; -.
DR InParanoid; Q7Z7B7; -.
DR OMA; NASRKCC; -.
DR OrthoDB; 1570128at2759; -.
DR PhylomeDB; Q7Z7B7; -.
DR PathwayCommons; Q7Z7B7; -.
DR Reactome; R-HSA-1461957; Beta defensins.
DR Reactome; R-HSA-1461973; Defensins.
DR SignaLink; Q7Z7B7; -.
DR BioGRID-ORCS; 400830; 12 hits in 1059 CRISPR screens.
DR GenomeRNAi; 400830; -.
DR Pharos; Q7Z7B7; Tdark.
DR PRO; PR:Q7Z7B7; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q7Z7B7; protein.
DR Bgee; ENSG00000186458; Expressed in corpus epididymis and 41 other tissues.
DR Genevisible; Q7Z7B7; HS.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0061827; C:sperm head; IDA:UniProtKB.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IC:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..95
FT /note="Beta-defensin 132"
FT /id="PRO_0000007007"
FT REGION 74..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 27..55
FT /evidence="ECO:0000250"
FT DISULFID 35..49
FT /evidence="ECO:0000250"
FT DISULFID 39..56
FT /evidence="ECO:0000250"
SQ SEQUENCE 95 AA; 10610 MW; DEFE657F7DA7A6DA CRC64;
MKFLLLVLAA LGFLTQVIPA SAGGSKCVSN TPGYCRTCCH WGETALFMCN ASRKCCISYS
FLPKPDLPQL IGNHWQSRRR NTQRKDKKQQ TTVTS
