ID   DB132_PANTR             Reviewed;          95 AA.
AC   Q30KJ7; A4H261;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 2.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Beta-defensin 132;
DE   AltName: Full=Defensin, beta 132;
DE   Flags: Precursor;
GN   Name=DEFB132;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012083; AAY59813.1; -; mRNA.
DR   EMBL; AM410166; CAL68976.1; -; Genomic_DNA.
DR   RefSeq; NP_001123255.1; NM_001129783.1.
DR   AlphaFoldDB; Q30KJ7; -.
DR   STRING; 9598.ENSPTRP00000022493; -.
DR   PaxDb; Q30KJ7; -.
DR   GeneID; 745492; -.
DR   KEGG; ptr:745492; -.
DR   CTD; 400830; -.
DR   eggNOG; ENOG502TE15; Eukaryota.
DR   InParanoid; Q30KJ7; -.
DR   OrthoDB; 1570128at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..95
FT                   /note="Beta-defensin 132"
FT                   /id="PRO_0000045357"
FT   REGION          76..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        27..55
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..49
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..56
FT                   /evidence="ECO:0000250"
FT   CONFLICT        65
FT                   /note="A -> P (in Ref. 1; AAY59813)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   95 AA;  10644 MW;  8AB70B4F24B8F076 CRC64;
     MNFLLLVLAA LGFLTQVIPA SAGGSKCVSN TPGYCRTYCH WGETALFMCN ASRKCCVSYS
     FLPKADLPRL IGNHWQSRRR NTQRKDKKQQ TTVTS