ID   DB133_HUMAN             Reviewed;          61 AA.
AC   Q30KQ1; Q4QY39;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Beta-defensin 133;
DE   AltName: Full=Defensin, beta 133;
DE   Flags: Precursor;
GN   Name=DEFB133;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 22-61.
RA   Patil A., Zhang G.;
RT   "Genome-wide analysis of rat beta-defensins: evidence for the existence of
RT   four syntenic defensin gene clusters in mammals.";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC   -!- CAUTION: Was termed (Ref.2) DEFB134. {ECO:0000305}.
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DR   EMBL; DQ012023; AAY59759.1; -; mRNA.
DR   EMBL; AY621330; AAT51869.1; -; mRNA.
DR   RefSeq; NP_001159950.1; NM_001166478.1.
DR   AlphaFoldDB; Q30KQ1; -.
DR   SMR; Q30KQ1; -.
DR   STRING; 9606.ENSP00000485031; -.
DR   BioMuta; DEFB133; -.
DR   DMDM; 84028894; -.
DR   PaxDb; Q30KQ1; -.
DR   PRIDE; Q30KQ1; -.
DR   Antibodypedia; 48482; 7 antibodies from 3 providers.
DR   UCSC; uc063ozl.1; human.
DR   GeneCards; DEFB133; -.
DR   HGNC; HGNC:31331; DEFB133.
DR   HPA; ENSG00000214643; Tissue enriched (epididymis).
DR   neXtProt; NX_Q30KQ1; -.
DR   PharmGKB; PA134862169; -.
DR   VEuPathDB; HostDB:ENSG00000214643; -.
DR   eggNOG; ENOG502TEXM; Eukaryota.
DR   HOGENOM; CLU_193926_0_0_1; -.
DR   InParanoid; Q30KQ1; -.
DR   OMA; KCRHECH; -.
DR   OrthoDB; 1618861at2759; -.
DR   PhylomeDB; Q30KQ1; -.
DR   PathwayCommons; Q30KQ1; -.
DR   Reactome; R-HSA-1461957; Beta defensins.
DR   Reactome; R-HSA-1461973; Defensins.
DR   BioGRID-ORCS; 403339; 4 hits in 178 CRISPR screens.
DR   Pharos; Q30KQ1; Tdark.
DR   PRO; PR:Q30KQ1; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q30KQ1; protein.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..61
FT                   /note="Beta-defensin 133"
FT                   /id="PRO_0000045358"
FT   DISULFID        31..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..52
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   61 AA;  7213 MW;  71C7575DECC65BFE CRC64;
     MKIHVFLFVL FFFLVPIATR VKCAVKDTYS CFIMRGKCRH ECHDFEKPIG FCTKLNANCY
     M