ID   DB133_PANTR             Reviewed;          62 AA.
AC   Q30KJ6;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Beta-defensin 133;
DE   AltName: Full=Defensin, beta 133;
DE   Flags: Precursor;
GN   Name=DEFB133;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012084; AAY59814.1; -; mRNA.
DR   RefSeq; NP_001123364.1; NM_001129892.1.
DR   AlphaFoldDB; Q30KJ6; -.
DR   STRING; 9598.ENSPTRP00000054243; -.
DR   PaxDb; Q30KJ6; -.
DR   GeneID; 740528; -.
DR   KEGG; ptr:740528; -.
DR   CTD; 403339; -.
DR   eggNOG; ENOG502TEXM; Eukaryota.
DR   InParanoid; Q30KJ6; -.
DR   OrthoDB; 1618861at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..62
FT                   /note="Beta-defensin 133"
FT                   /id="PRO_0000045359"
FT   DISULFID        32..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..53
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   62 AA;  7252 MW;  2A12917E076BE488 CRC64;
     MKIHIFLFVL FFFLVPIATR GVKCAVKDTY SCFIVRGKCR HECHDFEKPI GFCTKLNANC
     YM