ID   DB134_HUMAN             Reviewed;          66 AA.
AC   Q4QY38; A1L4A4;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Beta-defensin 134;
DE   AltName: Full=Defensin, beta 134;
DE   Flags: Precursor;
GN   Name=DEFB134;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Patil A., Zhang G.;
RT   "Genome-wide analysis of rat beta-defensins: evidence for the existence of
RT   four syntenic defensin gene clusters in mammals.";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC   -!- CAUTION: Was termed (Ref.2) DEFB135. {ECO:0000305}.
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DR   EMBL; DQ012024; AAY59760.1; -; mRNA.
DR   EMBL; AY621331; AAT51870.1; -; mRNA.
DR   EMBL; BC130461; AAI30462.1; -; mRNA.
DR   EMBL; BC130463; AAI30464.1; -; mRNA.
DR   CCDS; CCDS34847.1; -.
DR   RefSeq; NP_001289624.1; NM_001302695.1.
DR   RefSeq; XP_016869213.1; XM_017013724.1.
DR   RefSeq; XP_016885980.1; XM_017030491.1.
DR   RefSeq; XP_016885981.1; XM_017030492.1.
DR   RefSeq; XP_016885982.1; XM_017030493.1.
DR   AlphaFoldDB; Q4QY38; -.
DR   SMR; Q4QY38; -.
DR   STRING; 9606.ENSP00000435010; -.
DR   BioMuta; DEFB134; -.
DR   DMDM; 74762871; -.
DR   PaxDb; Q4QY38; -.
DR   PeptideAtlas; Q4QY38; -.
DR   PRIDE; Q4QY38; -.
DR   Antibodypedia; 50844; 7 antibodies from 3 providers.
DR   DNASU; 613211; -.
DR   Ensembl; ENST00000382205.4; ENSP00000371640.4; ENSG00000205882.8.
DR   Ensembl; ENST00000526438.5; ENSP00000435010.1; ENSG00000205882.8.
DR   Ensembl; ENST00000645046.1; ENSP00000494837.1; ENSG00000284754.1.
DR   Ensembl; ENST00000646417.1; ENSP00000495848.1; ENSG00000284754.1.
DR   GeneID; 613211; -.
DR   KEGG; hsa:613211; -.
DR   MANE-Select; ENST00000382205.6; ENSP00000371640.4; NM_001302695.2; NP_001289624.1.
DR   UCSC; uc011kxn.3; human.
DR   CTD; 613211; -.
DR   GeneCards; DEFB134; -.
DR   HGNC; HGNC:32399; DEFB134.
DR   HPA; ENSG00000205882; Tissue enriched (epididymis).
DR   neXtProt; NX_Q4QY38; -.
DR   OpenTargets; ENSG00000205882; -.
DR   PharmGKB; PA164718735; -.
DR   VEuPathDB; HostDB:ENSG00000205882; -.
DR   eggNOG; ENOG502TM3N; Eukaryota.
DR   GeneTree; ENSGT00400000024366; -.
DR   HOGENOM; CLU_2830492_0_0_1; -.
DR   InParanoid; Q4QY38; -.
DR   OMA; GICRFEC; -.
DR   OrthoDB; 1589658at2759; -.
DR   PhylomeDB; Q4QY38; -.
DR   PathwayCommons; Q4QY38; -.
DR   Reactome; R-HSA-1461957; Beta defensins.
DR   Reactome; R-HSA-1461973; Defensins.
DR   BioGRID-ORCS; 613211; 9 hits in 712 CRISPR screens.
DR   Pharos; Q4QY38; Tdark.
DR   PRO; PR:Q4QY38; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q4QY38; protein.
DR   Bgee; ENSG00000205882; Expressed in left testis and 41 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..66
FT                   /note="Beta-defensin 134"
FT                   /id="PRO_0000045360"
FT   DISULFID        32..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..52
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..59
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   66 AA;  7552 MW;  DA47541B373E1990 CRC64;
     MKPLLVVFVF LFLWDPVLAG INSLSSEMHK KCYKNGICRL ECYESEMLVA YCMFQLECCV
     KGNPAP