ID   DB134_PANTR             Reviewed;          59 AA.
AC   Q30KJ5;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Beta-defensin 134;
DE   AltName: Full=Defensin, beta 134;
DE   Flags: Precursor;
GN   Name=DEFB134;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012085; AAY59815.1; -; mRNA.
DR   RefSeq; NP_001123260.1; NM_001129788.1.
DR   AlphaFoldDB; Q30KJ5; -.
DR   SMR; Q30KJ5; -.
DR   PaxDb; Q30KJ5; -.
DR   GeneID; 737890; -.
DR   KEGG; ptr:737890; -.
DR   CTD; 613211; -.
DR   eggNOG; ENOG502TM3N; Eukaryota.
DR   HOGENOM; CLU_2830492_0_0_1; -.
DR   InParanoid; Q30KJ5; -.
DR   OrthoDB; 1589658at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..59
FT                   /note="Beta-defensin 134"
FT                   /id="PRO_0000045361"
FT   DISULFID        25..51
FT                   /evidence="ECO:0000250"
FT   DISULFID        31..45
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..52
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   59 AA;  6893 MW;  2A2D0C6062D1A17A CRC64;
     MKPLLVVFVF LFLWDPVLAE MHKKCYKNGI CRLECYESEM LVAYCMFQLE CCVKGNPAP