DB135_HUMAN
ID DB135_HUMAN Reviewed; 77 AA.
AC Q30KP9; Q4QY37;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Beta-defensin 135;
DE AltName: Full=Defensin, beta 135;
DE Flags: Precursor;
GN Name=DEFB135;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-66.
RA Patil A., Zhang G.;
RT "Genome-wide analysis of rat beta-defensins: evidence for the existence of
RT four syntenic defensin gene clusters in mammals.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC -!- CAUTION: Was termed (Ref.2) DEFB136. {ECO:0000305}.
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DR EMBL; DQ012025; AAY59761.1; -; mRNA.
DR EMBL; AY621332; AAT51871.1; -; mRNA.
DR CCDS; CCDS43710.1; -.
DR RefSeq; NP_001028189.2; NM_001033017.2.
DR RefSeq; XP_016885979.1; XM_017030490.1.
DR AlphaFoldDB; Q30KP9; -.
DR SMR; Q30KP9; -.
DR BioGRID; 534789; 235.
DR STRING; 9606.ENSP00000371643; -.
DR BioMuta; DEFB135; -.
DR DMDM; 84028897; -.
DR PaxDb; Q30KP9; -.
DR PRIDE; Q30KP9; -.
DR Antibodypedia; 50843; 5 antibodies from 1 providers.
DR DNASU; 613209; -.
DR Ensembl; ENST00000382208.3; ENSP00000371643.2; ENSG00000205883.3.
DR Ensembl; ENST00000645596.1; ENSP00000495605.1; ENSG00000285365.1.
DR GeneID; 613209; -.
DR KEGG; hsa:613209; -.
DR MANE-Select; ENST00000382208.3; ENSP00000371643.2; NM_001033017.3; NP_001028189.2.
DR UCSC; uc003wuw.1; human.
DR CTD; 613209; -.
DR GeneCards; DEFB135; -.
DR HGNC; HGNC:32400; DEFB135.
DR HPA; ENSG00000205883; Tissue enriched (epididymis).
DR neXtProt; NX_Q30KP9; -.
DR PharmGKB; PA165585476; -.
DR VEuPathDB; HostDB:ENSG00000205883; -.
DR eggNOG; ENOG502TF02; Eukaryota.
DR GeneTree; ENSGT00530000064429; -.
DR HOGENOM; CLU_181906_3_0_1; -.
DR InParanoid; Q30KP9; -.
DR OMA; NTCWRTK; -.
DR OrthoDB; 1609046at2759; -.
DR PhylomeDB; Q30KP9; -.
DR PathwayCommons; Q30KP9; -.
DR Reactome; R-HSA-1461957; Beta defensins.
DR Reactome; R-HSA-1461973; Defensins.
DR BioGRID-ORCS; 613209; 11 hits in 1062 CRISPR screens.
DR Pharos; Q30KP9; Tdark.
DR PRO; PR:Q30KP9; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q30KP9; protein.
DR Bgee; ENSG00000205883; Expressed in granulocyte and 67 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..77
FT /note="Beta-defensin 135"
FT /id="PRO_0000045362"
FT DISULFID 37..64
FT /evidence="ECO:0000250"
FT DISULFID 44..58
FT /evidence="ECO:0000250"
FT DISULFID 48..65
FT /evidence="ECO:0000250"
SQ SEQUENCE 77 AA; 8754 MW; 010E3EF6D54984F2 CRC64;
MATRSVLLAL VVLNLLFYVP PGRSGPNVYI QKIFASCWRL QGTCRPKCLK NEQYRILCDT
IHLCCVNPKY LPILTGK
