ID   DB135_PANTR             Reviewed;          78 AA.
AC   Q30KJ4;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Beta-defensin 135;
DE   AltName: Full=Defensin, beta 135;
DE   Flags: Precursor;
GN   Name=DEFB135;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ012086; AAY59816.1; -; mRNA.
DR   RefSeq; NP_001123263.1; NM_001129791.1.
DR   AlphaFoldDB; Q30KJ4; -.
DR   SMR; Q30KJ4; -.
DR   GeneID; 738168; -.
DR   KEGG; ptr:738168; -.
DR   CTD; 613209; -.
DR   InParanoid; Q30KJ4; -.
DR   OrthoDB; 1609046at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..78
FT                   /note="Beta-defensin 135"
FT                   /id="PRO_0000045363"
FT   DISULFID        37..64
FT                   /evidence="ECO:0000250"
FT   DISULFID        48..66
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  8725 MW;  75326A212F36CD0A CRC64;
     MATRSVLLAL VVLNLLFYVP PGRSGPNVYI QKIFASCWRL QGTCRPKCLK NETISYFGVI
     LYICGCVNPK YLPILTGK