DB136_HUMAN
ID DB136_HUMAN Reviewed; 78 AA.
AC Q30KP8; Q4QY36;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Defensin beta 136 {ECO:0000312|HGNC:HGNC:34433};
DE AltName: Full=Beta-defensin 136 {ECO:0000303|PubMed:16033865};
DE AltName: Full=DEFB137 {ECO:0000303|Ref.2};
DE Flags: Precursor;
GN Name=DEFB136;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-73.
RA Patil A., Zhang G.;
RT "Genome-wide analysis of rat beta-defensins: evidence for the existence of
RT four syntenic defensin gene clusters in mammals.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION.
RX PubMed=34481960; DOI=10.1016/j.pep.2021.105968;
RA Liu H., Diao H., Hou J., Yu H., Wen H.;
RT "Soluble expression and purification of human beta-defensin DEFB136 in
RT Escherichia coli and identification of its bioactivity.";
RL Protein Expr. Purif. 188:105968-105968(2021).
CC -!- FUNCTION: Host defense peptide that exhibits antibacterial and
CC antifungal activity (PubMed:34481960). Exhibits antimicrobial activity
CC against E.coli, S.aureus and C.albicans (in vitro) (PubMed:34481960).
CC Has high lipopolysaccharide (LPS)-binding affinity, and may thereby be
CC involved in immunoregulation through LPS neutralization
CC (PubMed:34481960). {ECO:0000269|PubMed:34481960}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60022}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC -!- CAUTION: Was termed (Ref.2) DEFB137. {ECO:0000305}.
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DR EMBL; DQ012026; AAY59762.1; -; mRNA.
DR EMBL; AY621333; AAT51872.1; -; mRNA.
DR CCDS; CCDS43709.1; -.
DR RefSeq; NP_001028190.2; NM_001033018.2.
DR RefSeq; XP_016885978.1; XM_017030489.1.
DR AlphaFoldDB; Q30KP8; -.
DR BioGRID; 534790; 78.
DR STRING; 9606.ENSP00000371644; -.
DR BioMuta; DEFB136; -.
DR DMDM; 84028899; -.
DR MassIVE; Q30KP8; -.
DR PaxDb; Q30KP8; -.
DR PeptideAtlas; Q30KP8; -.
DR PRIDE; Q30KP8; -.
DR Antibodypedia; 67428; 9 antibodies from 6 providers.
DR DNASU; 613210; -.
DR Ensembl; ENST00000382209.2; ENSP00000371644.2; ENSG00000205884.2.
DR Ensembl; ENST00000646795.1; ENSP00000494776.1; ENSG00000285087.1.
DR GeneID; 613210; -.
DR KEGG; hsa:613210; -.
DR MANE-Select; ENST00000382209.2; ENSP00000371644.2; NM_001033018.2; NP_001028190.2.
DR UCSC; uc011kxm.2; human.
DR CTD; 613210; -.
DR GeneCards; DEFB136; -.
DR HGNC; HGNC:34433; DEFB136.
DR HPA; ENSG00000205884; Tissue enhanced (epididymis).
DR neXtProt; NX_Q30KP8; -.
DR OpenTargets; ENSG00000205884; -.
DR PharmGKB; PA165585543; -.
DR VEuPathDB; HostDB:ENSG00000205884; -.
DR eggNOG; ENOG502R7G8; Eukaryota.
DR GeneTree; ENSGT00390000001862; -.
DR HOGENOM; CLU_198474_0_0_1; -.
DR InParanoid; Q30KP8; -.
DR OMA; WVAFCHN; -.
DR OrthoDB; 1577169at2759; -.
DR PhylomeDB; Q30KP8; -.
DR TreeFam; TF343350; -.
DR PathwayCommons; Q30KP8; -.
DR Reactome; R-HSA-1461957; Beta defensins.
DR Reactome; R-HSA-1461973; Defensins.
DR BioGRID-ORCS; 613210; 10 hits in 1026 CRISPR screens.
DR Pharos; Q30KP8; Tdark.
DR PRO; PR:Q30KP8; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q30KP8; protein.
DR Bgee; ENSG00000205884; Expressed in superior frontal gyrus and 63 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001530; F:lipopolysaccharide binding; IDA:UniProtKB.
DR GO; GO:0140367; P:antibacterial innate immune response; IDA:UniProtKB.
DR GO; GO:0061760; P:antifungal innate immune response; IDA:UniProtKB.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR InterPro; IPR035307; DEFB136/42.
DR PANTHER; PTHR39413; PTHR39413; 1.
DR Pfam; PF17333; DEFB136; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Fungicide;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..78
FT /note="Defensin beta 136"
FT /id="PRO_0000045364"
FT DISULFID 33..60
FT /evidence="ECO:0000250|UniProtKB:P81534"
FT DISULFID 40..54
FT /evidence="ECO:0000250|UniProtKB:P81534"
FT DISULFID 44..61
FT /evidence="ECO:0000250|UniProtKB:P81534"
SQ SEQUENCE 78 AA; 8755 MW; 26F291E8E0EF3A40 CRC64;
MNLCLSALLF FLVILLPSGK GMFGNDGVKV RTCTSQKAVC FFGCPPGYRW IAFCHNILSC
CKNMTRFQPP QAKDPWVH
