ID   DB136_PANTR             Reviewed;          78 AA.
AC   Q30KJ3;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Defensin beta 136 {ECO:0000250|UniProtKB:Q30KP8};
DE   AltName: Full=Beta-defensin 136 {ECO:0000303|PubMed:16033865};
DE   Flags: Precursor;
GN   Name=DEFB136;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Host defense peptide that exhibits antimicrobial and
CC       antifungal activity (By similarity). Exhibits antimicrobial activity
CC       against E.coli, S.aureus and C.albicans (in vitro) (By similarity). Has
CC       high lipopolysaccharide (LPS)-binding affinity, and may thereby be
CC       involved in immunoregulation through LPS neutralization (By
CC       similarity). {ECO:0000250|UniProtKB:Q30KP8}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60022}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012087; AAY59817.1; -; mRNA.
DR   RefSeq; NP_001123266.1; NM_001129794.1.
DR   AlphaFoldDB; Q30KJ3; -.
DR   STRING; 9598.ENSPTRP00000053236; -.
DR   PaxDb; Q30KJ3; -.
DR   Ensembl; ENSPTRT00000059955; ENSPTRP00000053236; ENSPTRG00000031029.
DR   GeneID; 738108; -.
DR   KEGG; ptr:738108; -.
DR   CTD; 613210; -.
DR   VGNC; VGNC:3023; DEFB136.
DR   eggNOG; ENOG502R7G8; Eukaryota.
DR   GeneTree; ENSGT00390000001862; -.
DR   HOGENOM; CLU_198474_0_0_1; -.
DR   InParanoid; Q30KJ3; -.
DR   OMA; WVAFCHN; -.
DR   OrthoDB; 1577169at2759; -.
DR   TreeFam; TF343350; -.
DR   Proteomes; UP000002277; Chromosome 8.
DR   Bgee; ENSPTRG00000031029; Expressed in cerebellar cortex and 5 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001530; F:lipopolysaccharide binding; ISS:UniProtKB.
DR   GO; GO:0140367; P:antibacterial innate immune response; ISS:UniProtKB.
DR   GO; GO:0061760; P:antifungal innate immune response; ISS:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR   InterPro; IPR035307; DEFB136/42.
DR   PANTHER; PTHR39413; PTHR39413; 1.
DR   Pfam; PF17333; DEFB136; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Fungicide;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..78
FT                   /note="Defensin beta 136"
FT                   /id="PRO_0000045365"
FT   DISULFID        33..60
FT                   /evidence="ECO:0000250|UniProtKB:P81534"
FT   DISULFID        40..54
FT                   /evidence="ECO:0000250|UniProtKB:P81534"
FT   DISULFID        44..61
FT                   /evidence="ECO:0000250|UniProtKB:P81534"
SQ   SEQUENCE   78 AA;  8788 MW;  714487243AEF3A58 CRC64;
     MNLCLSSLLF FLVILLPSGK GMFGNDGVKV RTCTSQKAVC FFGCPPGYRW IAFCHNILSC
     CKNMTRFQPL QAKDPWVH