ID   DBAA_EMENI              Reviewed;         584 AA.
AC   C8V4J5; Q5AUY4;
DT   13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=C6 finger domain transcription factor dbaA {ECO:0000303|PubMed:23001671};
DE   AltName: Full=Derivative of benzaldehyde biosynthesis cluster protein A {ECO:0000303|PubMed:23001671};
GN   Name=dbaA {ECO:0000303|PubMed:23001671}; ORFNames=ANIA_07896;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [3]
RP   IDENTIFICATION, INDUCTION, AND FUNCTION.
RX   PubMed=23001671; DOI=10.1128/aem.01808-12;
RA   Gerke J., Bayram O., Feussner K., Landesfeind M., Shelest E., Feussner I.,
RA   Braus G.H.;
RT   "Breaking the silence: protein stabilization uncovers silenced biosynthetic
RT   gene clusters in the fungus Aspergillus nidulans.";
RL   Appl. Environ. Microbiol. 78:8234-8244(2012).
RN   [4]
RP   INDUCTION.
RX   PubMed=25701285; DOI=10.1534/genetics.115.174342;
RA   Oiartzabal-Arano E., Garzia A., Gorostidi A., Ugalde U., Espeso E.A.,
RA   Etxebeste O.;
RT   "Beyond asexual development: modifications in the gene expression profile
RT   caused by the absence of the Aspergillus nidulans transcription factor
RT   FlbB.";
RL   Genetics 199:1127-1142(2015).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of the antibiotic
CC       2,4- dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA) and its
CC       derivatives (PubMed:23001671). Probably binds the conserved motif 5'-
CC       CT/CCG/AGA/CG/CT/A/CA/TT/A/GC-3' found in all dba cluster promoters and
CC       that shows significant similarities to the binding sites of other
CC       fungal C6 finger domain transcription factors (Probable).
CC       {ECO:0000269|PubMed:23001671, ECO:0000305|PubMed:23001671}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- INDUCTION: Deletion of the conserved eukaryotic csnE deneddylase
CC       subunit of the COP9 signalosome leading to defect in protein
CC       degradation results in the activation of the silenced dba gene cluster
CC       (PubMed:23001671). Expression is controlled by the transcription factor
CC       flbB (PubMed:25701285). {ECO:0000269|PubMed:23001671,
CC       ECO:0000269|PubMed:25701285}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA59550.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AACD01000135; EAA59550.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001302; CBF73479.1; -; Genomic_DNA.
DR   RefSeq; XP_681165.1; XM_676073.1.
DR   AlphaFoldDB; C8V4J5; -.
DR   SMR; C8V4J5; -.
DR   EnsemblFungi; CBF73479; CBF73479; ANIA_07896.
DR   EnsemblFungi; EAA59550; EAA59550; AN7896.2.
DR   GeneID; 2868948; -.
DR   KEGG; ani:AN7896.2; -.
DR   eggNOG; ENOG502SH49; Eukaryota.
DR   HOGENOM; CLU_011017_3_1_1; -.
DR   InParanoid; C8V4J5; -.
DR   OMA; CHTSSER; -.
DR   OrthoDB; 455010at2759; -.
DR   Proteomes; UP000000560; Chromosome II.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..584
FT                   /note="C6 finger domain transcription factor dbaA"
FT                   /id="PRO_0000446341"
FT   DNA_BIND        24..51
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   584 AA;  66143 MW;  3903B796A1208920 CRC64;
     MSQHVKSPEP TESPKPRQKP GAACEECRRR KLRCDRRQPQ CRLCEASGVE CQVITARPSR
     GPKPALEGAL LQQSTTNFSG PTDDHPLDTP MLDDQIDLSG WQLPVMDDES SLNGVYAASK
     ANSSSGTIMT NAGSGVNSIS PPHRSSSIPV ELTMPDVGSH IKGMENVEDI CEPKISDLIQ
     ADLDQLYFDR IHHFMPIQHQ SCYFSWRRQP IKTEAQSCLQ YAIWTLGASV SALHENIGHS
     FYQYARRGLE ALDSKNMSLA STDLEQVQAW LLLAIHEFMS VDFRRGWISA GRAFRLIQLN
     WLHGTDGWDL TRAQTDWIET EQKRRTFWMA YCLDRFMSMR TGSPPTFSER VAIRLPCPEA
     NFQNDQPILM GFLSDALAAD TSITSTFTEC IVVATISGRA LSHRNQCLAG DLYFSAVDDF
     WNRHQWINAI LTQRMEAFSA KYPLDMQQQT DPMLLFISLM WRTIILHLYQ TMACVIPSHD
     EKRDLVTEYK KRSSAAAQEI VDLTNKLSHL NSLKVHPLTP IPLSLCVEFL ILYHKPGDVF
     TKQLQDITEA MRNLKRFSNL GQEVLQLFDD QLLTTSPFQS STVH