DBAC_EMENI
ID DBAC_EMENI Reviewed; 98 AA.
AC C8V4J7;
DT 13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 1.
DT 25-MAY-2022, entry version 40.
DE RecName: Full=Derivative of benzaldehyde biosynthesis cluster protein C {ECO:0000303|PubMed:23001671};
GN Name=dbaC {ECO:0000303|PubMed:23001671}; ORFNames=ANIA_11584;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
RN [3]
RP IDENTIFICATION, INDUCTION, FUNCTION, DISRUPTION PHENOTYPE, AND PATHWAY.
RX PubMed=23001671; DOI=10.1128/aem.01808-12;
RA Gerke J., Bayram O., Feussner K., Landesfeind M., Shelest E., Feussner I.,
RA Braus G.H.;
RT "Breaking the silence: protein stabilization uncovers silenced biosynthetic
RT gene clusters in the fungus Aspergillus nidulans.";
RL Appl. Environ. Microbiol. 78:8234-8244(2012).
RN [4]
RP FUNCTION.
RX PubMed=22510154; DOI=10.1021/ja3016395;
RA Ahuja M., Chiang Y.M., Chang S.L., Praseuth M.B., Entwistle R.,
RA Sanchez J.F., Lo H.C., Yeh H.H., Oakley B.R., Wang C.C.;
RT "Illuminating the diversity of aromatic polyketide synthases in Aspergillus
RT nidulans.";
RL J. Am. Chem. Soc. 134:8212-8221(2012).
RN [5]
RP INDUCTION.
RX PubMed=25701285; DOI=10.1534/genetics.115.174342;
RA Oiartzabal-Arano E., Garzia A., Gorostidi A., Ugalde U., Espeso E.A.,
RA Etxebeste O.;
RT "Beyond asexual development: modifications in the gene expression profile
RT caused by the absence of the Aspergillus nidulans transcription factor
RT FlbB.";
RL Genetics 199:1127-1142(2015).
CC -!- FUNCTION: Part of the gene cluster that mediates the biosynthesis of
CC the antibiotic 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde
CC (DHMBA) and its derivatives (PubMed:22510154, PubMed:23001671). The
CC direct non-reducing polyketide synthase dbaI product is 2,4-dihydroxy-
CC 3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA), produced by condensation
CC of one acetyl-CoA starter unit with 4 malonyl-CoA units and one
CC methylation step (PubMed:22510154). The FAD-dependent monooxygenase
CC dbaH is responsible for the synthesis of yellow pigments derived from
CC the oxidation of DHMBA (PubMed:23001671). The roles of dbaB, C, E and F
CC have still to be determined (Probable). {ECO:0000269|PubMed:22510154,
CC ECO:0000269|PubMed:23001671, ECO:0000305|PubMed:23001671}.
CC -!- PATHWAY: Secondary metabolite biosynthesis.
CC {ECO:0000305|PubMed:23001671}.
CC -!- INDUCTION: Deletion of the conserved eukaryotic csnE deneddylase
CC subunit of the COP9 signalosome leading to defect in protein
CC degradation results in the activation of the silenced dba gene cluster
CC (PubMed:23001671). Expression is positively regulated by the dba
CC cluster specific transcription factor dbaA (PubMed:23001671).
CC Expression is also controlled by the transcription factor flbB
CC (PubMed:25701285). {ECO:0000269|PubMed:23001671,
CC ECO:0000269|PubMed:25701285}.
CC -!- DISRUPTION PHENOTYPE: Does not lead to any phenotypic changes.
CC {ECO:0000269|PubMed:23001671}.
CC -!- SIMILARITY: Belongs to the YciI family. {ECO:0000305}.
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DR EMBL; BN001302; CBF73482.1; -; Genomic_DNA.
DR AlphaFoldDB; C8V4J7; -.
DR SMR; C8V4J7; -.
DR EnsemblFungi; CBF73482; CBF73482; ANIA_11584.
DR eggNOG; ENOG502SC09; Eukaryota.
DR HOGENOM; CLU_110355_2_4_1; -.
DR InParanoid; C8V4J7; -.
DR OMA; YAKVGFW; -.
DR OrthoDB; 1510855at2759; -.
DR Proteomes; UP000000560; Chromosome II.
DR InterPro; IPR011008; Dimeric_a/b-barrel.
DR InterPro; IPR005545; YCII.
DR Pfam; PF03795; YCII; 1.
DR SUPFAM; SSF54909; SSF54909; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..98
FT /note="Derivative of benzaldehyde biosynthesis cluster
FT protein C"
FT /id="PRO_0000446356"
SQ SEQUENCE 98 AA; 10722 MW; C297ACCBCAECC7E0 CRC64;
MAQLYDWLVE TPANAEDLES RINTRPAHLE HNKPLIEAGT LVWGGPSLAA HPKAAGEDLA
IVGSVMCIRA GSEEEVREMI RNDPYAKLGQ VSIRMSVK
