DBAG_EMENI
ID DBAG_EMENI Reviewed; 420 AA.
AC Q5AUX9; A0A1U8QRB0; C8V4K1;
DT 13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Transcription factor dbaG {ECO:0000303|PubMed:23001671};
DE AltName: Full=Derivative of benzaldehyde biosynthesis cluster protein G {ECO:0000303|PubMed:23001671};
GN Name=dbaG {ECO:0000303|PubMed:23001671}; ORFNames=ANIA_07901;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
RN [3]
RP IDENTIFICATION, INDUCTION, FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=23001671; DOI=10.1128/aem.01808-12;
RA Gerke J., Bayram O., Feussner K., Landesfeind M., Shelest E., Feussner I.,
RA Braus G.H.;
RT "Breaking the silence: protein stabilization uncovers silenced biosynthetic
RT gene clusters in the fungus Aspergillus nidulans.";
RL Appl. Environ. Microbiol. 78:8234-8244(2012).
RN [4]
RP INDUCTION.
RX PubMed=25701285; DOI=10.1534/genetics.115.174342;
RA Oiartzabal-Arano E., Garzia A., Gorostidi A., Ugalde U., Espeso E.A.,
RA Etxebeste O.;
RT "Beyond asexual development: modifications in the gene expression profile
RT caused by the absence of the Aspergillus nidulans transcription factor
RT FlbB.";
RL Genetics 199:1127-1142(2015).
CC -!- FUNCTION: Transcription factor that coregulates the expression of the
CC gene cluster that mediates the biosynthesis of the antibiotic
CC 2,4- dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA) and its
CC derivatives (PubMed:23001671). Specifically positively regulates the
CC expression of the FAD-dependent oxidoreductase dbaF (PubMed:23001671).
CC {ECO:0000269|PubMed:23001671}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: Deletion of the conserved eukaryotic csnE deneddylase
CC subunit of the COP9 signalosome leading to defect in protein
CC degradation results in the activation of the silenced dba gene cluster
CC (PubMed:23001671). Expression is positively regulated by the dba
CC cluster specific transcription factor dbaA (PubMed:23001671).
CC Expression is also controlled by the transcription factor flbB
CC (PubMed:25701285). {ECO:0000269|PubMed:23001671,
CC ECO:0000269|PubMed:25701285}.
CC -!- DISRUPTION PHENOTYPE: Reduces the amounts of DHMBA produced and
CC strongly reduces the production of yellow pigmentation.
CC {ECO:0000269|PubMed:23001671}.
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DR EMBL; AACD01000135; EAA59555.1; -; Genomic_DNA.
DR EMBL; BN001302; CBF73490.1; -; Genomic_DNA.
DR RefSeq; XP_681170.1; XM_676078.1.
DR AlphaFoldDB; Q5AUX9; -.
DR EnsemblFungi; CBF73490; CBF73490; ANIA_07901.
DR EnsemblFungi; EAA59555; EAA59555; AN7901.2.
DR GeneID; 2868979; -.
DR KEGG; ani:AN7901.2; -.
DR eggNOG; ENOG502S3ED; Eukaryota.
DR HOGENOM; CLU_013866_1_1_1; -.
DR InParanoid; Q5AUX9; -.
DR OMA; VARCFLI; -.
DR OrthoDB; 1088940at2759; -.
DR Proteomes; UP000000560; Chromosome II.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..420
FT /note="Transcription factor dbaG"
FT /id="PRO_0000446357"
SQ SEQUENCE 420 AA; 45630 MW; B458A49985769D33 CRC64;
MPEDGPPKDI PDGLIEELAL RAFFHDYCVV PVNTALSRGY LGGLEPMVHR LGLQSPVANA
CKAVAFASHG LKLSRPFLTK KGEILYHELL GSLARSIQNP ALGAGPDIVV TAVLLGLYEM
IMAGESNPGH HNAHAGGMAA ILQIENSPLG LLQAARAGHP LVLNRMVQNN GMFISPSPGG
GGQSLDTILV KLGSLWQKSE TLLSNPQIPL FFDELYALRE ETTALNRDLI LWQKAQSDNF
KPTKVGYLSP SPYQLSPSAG FWPGQVDTYV DLYVAGVWNV SRVARCFLIN LIVRLSNILD
PTSDHRQYHN DVRELVGDIF ASIPFHLTED LGAFVAKRGA NPEIANPGRP VGGLILLHPV
YIASQLPVVP PDMQEYMRKC LAWIGKYMGI GQACLLAKAP RVEGQYFACG CMLVWAGLLI
